Minoxidil

  • U-10,858
  • Aalopexil
  • Alostil
  • 6-Amino-1,2-dihydro-1-hydroxy-2-Imino-4-piperidinopyrimidine
  • 2,4-Diamino-6-piperidinopyrimidine 3-oxide
  • 2,3-Dihydro-3-hydroxy-2-Imino-6-(1-piperidinyl)-4-pyrimidinamine
Formula
C9H15N5O
Structure
Description
Crystals from methanol-acetonitrile. Odorless. Solutions are colorless to light yellow.
Uses
Medication.

Registry Numbers and Inventories.
CAS
38304-91-5
EC (EINECS/ELINCS)
253-874-2
RTECS
UV8200000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,6290
Beilstein/Gmelin
886240
Beilstein Reference
5-25-12-00317
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C9H15N5O
Formula mass
209.25
Melting point, °C
248
pKa/pKb
4.61 (pKa)

Hazards and Protection.
Storage
Keep in a cool, dry location. Keep containers closed when not in use. Protect from light.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Absorb spilled solutions wiht papter towls or other appropriate media. For solid, sweep up. Transfer to suitable container for later disposal.
Stability
Stable at normal temperatures and pressures.

Fire.
Fire fighting
Extinguish using water, carbon dixoide or dry chemical powder. Use a SCBA and full-body protective equipment.

Health.
Exposure effects
Headache, dizziness and sweating may occur with any of the vasodilators. Peripheral neuropathy has been reported following long term hydralazine therapy. Hyperglycemic, non-ketotic coma may occur with diazoxide. Seizures and coma may occur with buflomedil toxicity.
   Ingestion
Nausea and vomiting are common following therapeutic administration of fenoldopam.
   Inhalation
Pulmonary edema has been reported following buflomedil overdoses. Respiratory depression may occur with buflomedil intoxication.
   Skin
May cause irritation, allergic contact dermatitis.
   Eyes
Burns, irritation.

First aid
 
   Ingestion
Immediately seek medical assistance.
   Inhalation
Remove from exposure. Seek medical assistance.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with copious amounts of water. Seek medical assistance.

Transport.