Misoprostol

  • Cytotec
  • Misoprostil
  • Prost-13-en-1-oic acid, 11,16-dihydroxy-16-methyl-9-oxo-, methyl ester, (11a,13E)-
Formula
C22H38O5
Structure
Description
Light yellow oil.
Uses
Anti-ulcerative.

Registry Numbers and Inventories.
CAS
59122-46-2
RTECS
UK8390000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,6297
Beilstein/Gmelin
4155643

Properties.
Formula
C22H38O5
Formula mass
382.54
Solubility in water
Insoluble
pKa/pKb
13.92 (pKa)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Elevated body temperature, increased pulse, and increased respiratory rate may result from an acute overdose. therapeutic side effects have included headache, dizziness, fatigue, and malaise. Seizures are possible. Tremor was reported in one overdose. Women should be advised not to become pregnant while taking misoprostol. If pregnancy is suspected, use of the product should be discontinued and the pregnancy should be followed very closely (weekly) for the next 4 weeks. <br>Mobius' syndrome (congenital facial paralysis) were reported following maternal misoprostol administration.
   Ingestion
Gastrointestinal side effects include nausea (2% to 5%), vomiting (0.9%), diarrhea (3% to 13%), abdominal pain (17%), and constipation (0.6% to 2%). Nausea and abdominal cramping were reported in two overdose ingestions.
   Inhalation
Hypoxemia and respiratory alkalosis has been observed following an acute overdose.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.