Mometasone furoate

  • Pregna-1,4-diene-3,20-dione, 9,21-dichloro-17-((2-furanylcarbonyl)oxy)-11-hydroxy-16-methyl-, (11-beta,16-alpha)
  • Mometasone 17-(2-furoate)
Formula
C27H30Cl2O6
Structure
Description
Distributed as 0.1% ointment with a petrolatum base.
Uses
Anti-inflammatory

Registry Numbers and Inventories.
CAS
83919-23-7
RTECS
TU3822000
Merck
12,6324
Beilstein/Gmelin
4340538

Properties.
Formula
C27H30Cl2O6
Formula mass
521.44
Melting point, °C
218 - 220
Vapor pressure, mmHg
4.5E-18 (25 C)
Density
1.37 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
13.05 (pKa)
Partition coefficient, pKow
4.27

Hazards and Protection.
Storage
Keep container tightly sealed. Store in cool, dry conditions in well sealed containers.
Protection
Protective work clothing. Chemical protective gloves. Safety glasses or goggles.
Small spills/leaks
Assure slippery conditions are nullified. Add sand or dirt. Scoop up and remove, Wash area with soap and water.
Stability
Stable if stored as directed.
Incompatibilities
Oxidizing agents, bases.

Fire.
Fire fighting
Extinguish with carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Wear self-contained respirator. Wear fully protective impervious suit.
Combustion products
May emit toxic fumes.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
May cause irritation of the eyes and skin. May cause reversible suppression of the Hypothalamic-Pituitary-Adrenal Axis, symptoms of Cushing’s Syndrome, hyperglycemia and glycosuria if ingested.

First aid
 
   Ingestion
Give two glasses of water and induce vomiting. Never give anything by mouth to an unconscious person.
   Inhalation
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Seek immediate medical advice.
   Skin
Wash thoroughly with soap and water.
   Eyes
Flush with plenty of water for at least 15 minutes.

Transport.