Monocrotaline

  • 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-
Formula
C16H23NO6
Structure
Description
Prisms from abs ethanol.
Uses
Used experimentally in animals to induce pulmonary hypertension.

Registry Numbers and Inventories.
CAS
315-22-0
RTECS
QB3140000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Natural Product
UN (DOT)
2811
Merck
12,6333
Beilstein/Gmelin
48732
Beilstein Reference
4-27-00-06660

Properties.
Formula
C16H23NO6
Formula mass
325.36
Melting point, °C
203
Solubility in water
Slightly soluble
pKa/pKb
8.51 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
ELIMINATE all ignition sources. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
Volatility very slight; stable for long periods at room temperature in closed containers.
Decomposition
When heated to decomposition it emits toxic fumes of nitrogen oxides.

Fire.
Fire fighting
Extinguish using agent most appropriate for surrounding fire.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-2B, CP65
Exposure effects
headache as well as apathy has been reported.
   Ingestion
See Inhalation.
   Inhalation
Right pleural effusion was seen in a 6-month-old given PA-containing herbal tea.
   Skin
Contact with molten substance may cause severe burns to skin and eyes. See Inhalation.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Seek medical assistance.
   Inhalation
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush with running water for at least 20 minutes.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III