Morpholine

  • Tetrahydro-2H-1,4-oxazine
  • Tetrahydro-1,4-oxazine
  • Tetrahydro-p-isoxazine
  • 1-Oxa-4-azacyclohexane
  • Diethylene oximide
  • Diethylenimide oxide
Formula
C4H9NO
Structure
Description
Colorless, mobile liquid, characteristic, unpleasant, amine-like odor, hygroscopic.
Uses
Solvent for resins, waxes, casein, dyes.

Registry Numbers and Inventories.
CAS
110-91-8
EC (EINECS/ELINCS)
203-815-1
EC Index Number
613-028-00-9
EC Class
Flammable; Harmful; Corrosive
R 10 20/21/22 34
S 23 36 45
RTECS
QD6475000
RTECS class
Tumorigen; Mutagen; Primary Irritant
UN (DOT)
2054
Merck
12,6362
Beilstein/Gmelin
102549
Beilstein Reference
4-27-00-00015
EPA OPP
54701
Swiss Giftliste 1
G-2552
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C4H9NO
Formula mass
87.12
Melting point, °C
-5
Boiling point, °C
128.9
Vapor pressure, mmHg
6 (25 C)
Vapor density (air=1)
3.0
Saturation Concentration
10500 ppm at 20 C
Evaporization number
Less than 1 (butyl acetate = 1)
Odor Threshold Odor threshold 0.1 ppm
Critical temperature
344
Critical pressure
52.3
Density
1.01918 g/cm3 (0 C)
Solubility in water
Miscible
Viscosity
2.04 cp (25 C)
Surface tension
37.5 g/s2 @ 20 C
Refractive index
1.4543 (15 C)
Dipole moment
1.58 D (20 C)
Dielectric constant
7.3 (20 C)
pKa/pKb
5.51 (pKb)
Partition coefficient, pKow
-0.86
Heat of vaporization
45.55 kJ/mol
Heat of combustion
-2673 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
B2 D1B E
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Disposal code
5
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Acids, organic anhydrides, isocyanates, vinyl acetate, acrylates, substituted allyls, alkylene oxides, epichlorohydrin, ketones, aldehydes, alcohols, glycols, phenols, cresol, caprolactam solution, strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, ammonia and/or derivatives.

Fire.
Flash Point,°C
38
Autoignition, °C
4310
Upper exp. limit, %
11.0
Lower exp. limit, %
1.8
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water.
Fire potential
Flammable/combustible material.
Hazards
Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Combustion products
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Health
3
 
Flammability
3
 
 
Reactivity
1
 

Health.
Exposure limit(s)
OSHA PEL: TWA 20 ppm (70 mg/m3) skin NIOSH REL: TWA 20 ppm (70 mg/m3) ST 30 ppm (105 mg/m3) skin NIOSH IDLH: 1400 ppm LEL
Poison_Class
3
Exposure effects
Prolonged or repeated exposure through any route may cause liver, kidney and lung damage.
   Ingestion
May cause severe and permanent damage to the digestive tract. Aspiration hazard. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Causes gastrointestinal tract burns. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause liver and kidney damage. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
   Inhalation
Irritation may lead to chemical pneumonitis and pulmonary edema. May cause liver and kidney damage. May cause severe irritation of the upper respiratory tract with pain, burns, and inflammation. Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
   Skin
Contact with liquid is corrosive and causes severe burns and ulceration. Substance is rapidly absorbed through the skin. May cause irritation and dermatitis. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
   Eyes
May cause severe eye irritation. Causes eye burns. Vapor or mist may cause irritation and severe burns. Contact with liquid is corrosive to the eyes and causes severe burns. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Transport.
UN number
2054
Response guide
Hazard class
8
Packing Group
I
 
USCG CHRIS Code
MPL
 
7 Aliphatic amines
HS Code
2934 99 90
 
Std. Transport #
4935668
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S