Mytelase chloride

  • Ambenonium chloride
  • Ammonium, (oxalylbis(iminoethylene))bis((o-chlorobenzyl)diethyl-, dichloride
  • [Oxalylbis(iminoethylene)] bis[(o-chlorobenzyl)diethylammonium] dichloride
  • N,N'-Bis-2-[(2-chlorobenzyl)diethylammonium chloride]-ethyloxamide
  • N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, dichloride

Registry Numbers and Inventories.

Formula mass
Melting point, °C
196 - 199
Solubility in water

Hazards and Protection.
Wear safety glasses with side shields or goggles where risk of eye exposure exists. Impervious gloves should be worn.
None normally required. However, a respiratory protection program that meets OSHA 29 CFR 1910.134 and ANSI Z88.2 requirements must be followed whenever workplace conditions warrant respirator usage.
Small spills/leaks
Wet-down all dusts and soak up contents of broken tablets with an absorbent material. Carefully collect material and place in a properly labeled waste container for disposal. Wash area of spill to remove from surfaces. Wash skin thoroughly after handling.
Stable at normal temperatures and pressures.

Fire fighting
Extinguish with Water spray, carbon dioxide or dry chemical powder. Use pressure demand self-contained breathing apparatus (SCBA) and protective clothing to prevent contact with skin and eyes. Use water spray to keep fire exposed containers cool.
May emit hydrogen chloride, nitrogen oxide and sulfur oxides under fire conditions.

Exposure effects
This product is a cholinesterase inhibitor with prolonged duration of action. Mytelase has all the pharmacological actions of acetylcholine (both the muscurinic and nicotinic).
Cholinesterase inhibitor. In general, early symptoms are minimal, but may include headache, nausea, and dizziness Effects generally progress rapidly, and may include excessive salivation, abdominal cramps, diarrhea, contraction of the pupils in the eyes, blurring of vision, urgent need to urinate, cold sweating, paleness, and vomiting. In cases of serious overexposure effects may progress to include muscle twitching, weakness and paralysis of voluntary muscles including the tongue (producing a sensation of “thick tongue,” along with difficulty swallowing, shoulders, neck and arms. Blood pressure may increase, with or without a slowing of heart rate. A sensation of internal trembling, severe anxiety, and panic may result. Death may occur rapidly if untreated.
The effects of inhaling dust from crushed or broken tablets have not been determined: Effects may be presumed to be similar to those, which may occur following ingestion.
Causes irritation.
Eye contact may lead to blurring of vision.

First aid
In case of acute overdose by ingestion, seek immediate medical attention.
Dust containing drug substance could be inhaled if tablets are crushed or broken. If dust is inhaled, remove to fresh air. Seek medical attention.
Overt contamination of clothing is unlikely. However, in the event dust from broken or crushed tablets comes in contact with skin and clothing, remove contaminated clothing and wash thoroughly with running water. Use soap if available. Seek medical attention if irritation develops.
In case of contact with dust from crushed or broken tablets, flush eyes thoroughly with running water. Seek medical attention if irritation develops.