m-Chlorophenol

  • 3-Hydroxychlorobenzene
  • 3-Chlorophenol
  • 3-Chloro-1-hydroxybenzene
Formula
3-(Cl)C6H4OH
Structure
Description
White, needle-like crystals, distinct odor, similar to phenol. Some discoloration on exposure to light and air.
Uses
Intermediate in organic synthesis.

Registry Numbers and Inventories.
CAS
108-43-0
EC (EINECS/ELINCS)
203-582-6
EC Index Number
604-008-00-0
EC Class
Harmful; Dangerous for the Environment
R 20/21/22 51/53
RTECS
SK2450000
RTECS class
Tumorigen; Mutagen
UN (DOT)
2020
Merck
13,2173
Beilstein/Gmelin
1634401
Beilstein Reference
4-06-00-00810
Swiss Giftliste 1
G-180663
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C6H5ClO
Formula mass
128.56
Melting point, °C
31 - 34
Boiling point, °C
214
Vapor pressure, mmHg
1
Saturation Concentration
6580 ppm (0.66%) at 72 C (calculated)
Odor Threshold Odor threshold 0.18 ppb
Critical temperature
441
Critical pressure
54.1
Density
1.245 g/cm3 (20 C)
Solubility in water
26 g/L
Viscosity
11.55 cp @ 25C
Refractive index
1.5565 (40 C)
pKa/pKb
9.12 (pKa)
Partition coefficient, pKow
2.5
Heat of vaporization
69.4 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Oxidizing agents, acid chlorides, acid anhydrides, moisture.
Decomposition
Hydrogen chloride, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
97
Autoignition, °C
> 600
Upper exp. limit, %
8.8
Lower exp. limit, %
1.7
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
This chemical is probably combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-2B
Poison_Class
3
Exposure effects
Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.
   Ingestion
May cause irritation of the digestive tract. May be harmful if swallowed.
   Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2020
Response guide
Hazard class
6.1
Packing Group
III
 
HS Code
2908 10 00