m-Nitrophenol

  • 3-Nitrophenol
  • 1-Hydroxy-3-nitrobenzene
Formula
O2NC6H4OH
Structure
Description
Colorless to pale yellow crystalline solid.
Uses
As indicator in 0.3% Soln in 50% alcohol ph: 6.8 Colorless, 8.6 Yellow.

Registry Numbers and Inventories.
CAS
554-84-7
EC (EINECS/ELINCS)
209-073-5
EC Class
harmful, irritant
R 20/21/22 33 36/37/38 43
S 26 36/37/39
RTECS
SM1925000
RTECS class
Mutagen; Primary Irritant
UN (DOT)
1663
Merck
12,6716
Beilstein/Gmelin
1907946
Beilstein Reference
4-06-00-01269
Swiss Giftliste 1
G-181527
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C6H5NO3
Formula mass
139.11
Melting point, °C
94 - 95
Boiling point, °C
271
Vapor pressure, mmHg
0.004 (25 C)
Vapor density (air=1)
4.8
Odor Threshold Odor threshold 3.0 mg/m3
Density
1.485 g/cm3 (20 C)
Solubility in water
30 g/L
Viscosity
0.973 cp (184 C)
Surface tension
36.5 g/s2 (184 C)
pKa/pKb
8.33 (pKa)
Partition coefficient, pKow
2.00
Heat of fusion
20.54 kJ/mol
Heat of vaporization
53.0 kJ/mol
Heat of combustion
-2875 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.
Disposal code
3
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents; Strong bases.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
101.7
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
Nitrophenol is combustible though it may take some effort to ignite. Nitrophenol aromatic nitrocompounds are flammable.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Dangerous toxic fumes of NO x
Health
2
 
Flammability
1
 
 
Reactivity
0
 

Health.
Poison_Class
2
Exposure effects
Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.
   Inhalation
May cause respiratory tract irritation. May cause effects similar to those described for ingestion. May cause drowsiness, unconsciousness, and central nervous system depression.
   Skin
Causes skin irritation. May be absorbed through the skin in harmful amounts. If absorbed, may cause symptoms similar to those for ingestion.
   Eyes
Causes severe eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Remove contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1663
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
NIP
 
HS Code
2908 90 00