m-Toluidine

  • m-Methylaniline
  • 3-Aminophenylmethane
  • 3-Aminotoluene
Formula
3-(CH3)C6H4NH2
Structure
Description
Colorless to light yellow liquid, aromatic, aniline-like odor.
Uses
Manufacture dyes and other organic chemicals.

Registry Numbers and Inventories.
CAS
108-44-1
EC (EINECS/ELINCS)
203-583-1
EC Index Number
612-024-00-4
EC Class
Toxic; Danger of cumulative effects; Dangerous for the Environment
R 23/24/25 33 50
S 28 36/37 45 61
RTECS
XU2800000
RTECS class
Primary Irritant
UN (DOT)
1708
Merck
12,9674
Beilstein/Gmelin
635944
Beilstein Reference
4-12-00-01813
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9N
Formula mass
107.16
Melting point, °C
-30
Boiling point, °C
203
Vapor pressure, mmHg
0.3
Saturation Concentration
1316 ppm (0.1%) at 41 C (calculated)
Critical temperature
436
Critical pressure
39.68
Density
0.98444 g/cm3
Solubility in water
20 g/L
Viscosity
3.32 cp (25 C)
Surface tension
36.9 g/s2
Refractive index
1.56293 (15 C)
pKa/pKb
9.30 (pKb)
Partition coefficient, pKow
1.40
Heat of vaporization
45.64 kJ/mol
Heat of combustion
-4043 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.
Incompatibilities
Strong oxidizing agents - strong acids - air - light.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
90
Autoignition, °C
> 500
Upper exp. limit, %
7.6
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Flammable when exposed to heat or flame.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic oxides of nitrogen and flammable vapors may form in fire.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 2 ppm; 8.8 mg/m3 (as TWA) (skin) (ACGIH 1994-1995). NIOSH REL: See Appendix D
Exposure effects
Chronic inhalation may cause effects similar to those of acute inhalation. May cause kidney injury. Absorption into the body leads to the formation of methemoglobin which in sufficient concentrations causes cyanosis. May cause anemia and other blood cell abnormalities. Contact with the skin may cause cutaneous lesions.
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract. May cause effects similar to those for inhalation exposure. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Overexposure may cause methemoglobinemia.
   Inhalation
Causes cyanosis, characterized by bluish-colored skin. May cause anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood.
   Skin
Causes skin irritation. May be absorbed through the skin. Causes symptoms similar to those of inhalation. Excessive drying of the skin may result form repeated or prolonged contact.
   Eyes
Causes severe eye irritation. May cause severe eye burns.

First aid
 
   Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1708
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
TOI
 
9 Aromatic amines
HS Code
2921 43 00
 
Std. Transport #
4913152