m-Tolyl isocyanate

  • 3-Tolyl isocyanate
  • m-Isocyanatotoluene
  • 3-Methylphenyl isocyanate
  • 1-Isocyanato-3-methylbenzene
  • Isocyanic acid, m-tolyl ester
Formula
C8H7NO
Structure
Description
Clear yellow liquid.

Registry Numbers and Inventories.
CAS
621-29-4
EC (EINECS/ELINCS)
210-676-0
R 23/25 36/37/38 42
S 23 26 36/37/39 45
UN (DOT)
3080
Beilstein/Gmelin
386149
Beilstein Reference
4-12-00-01831
Canada DSL/NDSL
NDSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C8H7NO
Formula mass
133.15
Melting point, °C
195 - 198
Boiling point, °C
90 (30 torr)
Vapor density (air=1)
4.59
Density
1.033 g/cm3
Solubility in water
Insoluble
Refractive index
1.53 (20 C)

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Do not get on skin and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not allow contact with water. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam. Do not breathe vapors.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Use a spark-proof tool. Provide ventilation. Do not get water inside containers.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Moisture, heat, alcohols, strong bases, amines, acids, strong oxidizing agents, water.
Decomposition
Hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Extinguishing media: Use water spray to cool fire-exposed containers. Do NOT get water inside containers. Use dry powder or carbon dioxide.
Fire potential
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.
Hazards
Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.
Combustion products
Fire will produce irritating, corrosive and/or toxic gases.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure effects
Repeated exposure may cause allergic respiratory reaction (asthma). Prolonged or repeated exposure may cause lung irritation, chest pain, and pulmonary edema.
   Ingestion
Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Aspiration may lead to pulmonary edema. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. Inhalation at high concentrations may cause CNS depression and asphixiation. Harmful if inhaled. May cause respiratory sensitization.
   Skin
Harmful if absorbed through the skin. May cause irritation and dermatitis. May cause cyanosis of the extremities. May cause sensitization by skin contact.
   Eyes
May cause eye irritation. Lachrymator. May cause chemical conjunctivitis and corneal damage.

First aid
 
   Ingestion
Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. May cause irritation of the digestive tract and possible burns.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
3080
Response guide
Hazard class
6.1
Packing Group
II