N-Ethyl-N-(2-chloroethyl)aniline

  • N-(2-Chloroethyl)-N-ethylaniline
  • Ethyl(chloroethyl)aniline
  • 2-(N-Ethylanilino)ethyl chloride
Formula
C10H14ClN
Structure
Description
Needles from alcohol.
Uses
A metabolite of alkoxyaniline mustards in microsomal suspensions.

Registry Numbers and Inventories.
CAS
92-49-9
EC (EINECS/ELINCS)
202-159-3
RTECS
BX1300000
RTECS class
Other
UN (DOT)
2018
Beilstein/Gmelin
1073025
Beilstein Reference
3-12-00-00263
Canada DSL/NDSL
NDSL
US TSCA
Listed
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H14ClN
Formula mass
183.70
Melting point, °C
45.5-46.5
Boiling point, °C
163 - 164 (42 torr)
Solubility in water
Insoluble
pKa/pKb
6.69 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Stability
No data.

Fire.
Fire fighting
Small Fires: Dry chemical, carbon dioxide or water spray. Large Fires: Water spray, fog or regular foam.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Containers may explode when heated.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure effects
Dyspnea and paroxysmal cough are common. Fever may occur. Dizziness, malaise, anorexia, lethargy can occur after acute exposure. Intellectual dullness is common. Probable human teratogen.
   Ingestion
Nausea, vomiting, diarrhea and epigastric pain can be caused either by ingestion or systemic absorption.
   Inhalation
Irritation or ulceration of the respiratory tract can occur from inhalation; lesions may be fatal. Respiratory impairment may be delayed and severe. Pulmonary edema may occur.
   Skin
Severe irritation was produced from doses as low as 65 mcg in humans. The first effect on skin is redness, similar to a sunburn.
   Eyes
Severe eye irritant inducing edema, burning discomfort, photophobia, tearing, and/or blepharospasm. Ulceration of the cornea and/or BLINDNESS ranging from burning discomfort to destruction of the eyeball may occur after severe exposure. Local ischemia/thrombosis with delayed hemorrhage has developed several days after exposure. The mechanism of action is not known, but it could be immune system mediated.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Time is of the essence - immediately remove the victim from the contaminated area, stabilize the hemodynamic status, provide oxygen and manage airway aggressively.
   Skin
There is no specific antidote once the mustard gas has reached the cells. Decontaminate by washing with water and neutralizing with a 2.5 Percent solution of sodium thiosulfate. Oral prednisone, topical antiseptic solutions and a regimen of vitamin e may be beneficial; promethazine or antihistamines have been used. Antimicrobial ointments should be applied to blisters. Treat systematic effects as outlined in the inhalation exposure section. The us military previously used the m2581a skin decontamination kit containing towelettes soaked with phenol+hydroxide and chloramine. This has been replaced with the resins ambergard xe-555 and xe-556. Expedients which may be used include powders such as talcum powder, flour, and fuller's earth. Dilute (0.5 Percent) hypochlorite (bleach) solutions can also be used.
   Eyes
Irrigate thoroughly with water and neutralize with a 2.5 percent solution of sodium thiosulfate. Treat systematic effects as outlined in the inhalation exposure section.

Transport.
UN number
2018
Response guide
Hazard class
6.1
Packing Group
II