N-Ethylmaleimide

  • Maleic acid n-ethylimide
  • 1-Ethyl-1H-pyrrole-2,5-dione
  • Cryptopyrrole
Formula
C6H7NO2
Structure
Description
White solid with a strong, pungent odor.
Uses
Substance is used in cancer research (possible antimitotic activity.)

Registry Numbers and Inventories.
CAS
128-53-0
EC (EINECS/ELINCS)
204-892-4
R 28 23/24 34 43
S 26 28 36/37/39 45
RTECS
UX9625000
RTECS class
Mutagen
UN (DOT)
2811
Merck
13,3855
Beilstein/Gmelin
112448
Beilstein Reference
5-21-10-00006
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C6H7NO2
Formula mass
125.13
Melting point, °C
46
Boiling point, °C
210
Vapor pressure, mmHg
0.2 (25 C)
Vapor density (air=1)
4.3
Solubility in water
Soluble
Partition coefficient, pKow
0.68
Heat of vaporization
44.6 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong acids, strong bases.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
73
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
3
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
   Ingestion
May cause severe irritation of the digestive tract.
   Inhalation
May cause severe respiratory tract irritation.
   Skin
Causes skin burns.
   Eyes
Causes eye burns. Lachrymator. May cause corneal edema and inflammation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Discard contaminated clothing in a manner which limits further exposure.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed.

Transport.
UN number
2811
Response guide
Hazard class
6.1
Packing Group
I; II; III