N-Isopropyl-N'-phenyl-1,4-phenylenediamine

  • 4-(Isopropylamino)diphenylamine
  • N-(1-Methylethyl)-N-phenyl-1,4-benzenediamine
  • N-Isopropyl-N'-Phenyl-p-phenylenediamine
Formula
C15H18N2
Structure
Description
Dark gray to black flakes or brown-black small chip-like solid with an aromatic odor.
Uses
Protection of rubbers against oxidation, ozone, flexcracking, and poisoning by copper and manganese.

Registry Numbers and Inventories.
CAS
101-72-4
EC (EINECS/ELINCS)
202-969-7
EC Index Number
612-136-00-3
EC Class
Harmful; Sensitising; Dangerous for the Environment
RTECS
ST2650000
RTECS class
Primary Irritant
UN (DOT)
1673
Beilstein/Gmelin
2213195
Beilstein Reference
4-13-00-00115
Swiss Giftliste 1
G-5252
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C15H18N2
Formula mass
226.35
Melting point, °C
79
Boiling point, °C
378
Vapor pressure, mmHg
0.00343 (25 C)
Critical temperature
549
Critical pressure
25.3
Density
1.04 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
7.24 (pKb)
Partition coefficient, pKow
2.83
Heat of vaporization
62.6 kJ/mol

Hazards and Protection.
Storage
Store in a cool, dry location. Keep away from heated pipes, ducts and direct sunlight.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable.
Incompatibilities
Reacts with oxidizing agents Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.

Fire.
Flash Point,°C
230
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
Fire potential
This chemical is combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Exposure limit(s)
OEL-RUSSIA: STEL 2 mg/m3
Poison_Class
4
Exposure effects
Abnormally low blood pressure and labored respirations may occur. CNS depression and peripheral neuropathy have been reported after ingestion.
   Ingestion
Epigastric pain and recurrent vomiting are common shortly following ingestion.
   Inhalation
Bronchospasm may develop in sensitized individuals.
   Skin
Contact dermatitis is common.
   Eyes
Significant laryngeal and facial edema may occur. Breathing may be impaired as a result of laryngeal edema. Immediate (usually) or delayed hypersensitivity reactions have been described following application of PPD-containing hair dyes to eyebrows or eyelashes. Eye pain and burning, and edema occur, which may progress to widespread facial edema, dermatitis, tearing, photophobia, uveitis, and keratitis. Corneal necrosis and vision loss may occur. Bilateral optic neuritis has been reported with blindness.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1673
Response guide
Hazard class
6.1
Packing Group
III
 
9. Aromatic amines