N-Methyl-2-pyrrolidone

  • N-Methylpyrrolidone
  • 1-Methyl-2-pyrrolidone
  • 1-Methyl-2-pyrrolidinone
Formula
C5H9NO
Structure
Description
Colorless liquid, amine-like odor, hygroscopic.
Uses
Solvent for resins, acetylene, etc., Pigment dispersant, petroleum processing, spinning agent for polyvinyl chloride, microelectronics industry plastic solvent applications, intermediate.

Registry Numbers and Inventories.
CAS
872-50-4
EC (EINECS/ELINCS)
212-828-1
EC Index Number
606-021-00-7
EC Class
Irritant
R 36/38
RTECS
UY5790000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
1760
Merck
12,6197
Beilstein/Gmelin
106420
Beilstein Reference
5-21-06-00321
Swiss Giftliste 1
G-2530
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C5H9NO
Formula mass
99.13
Melting point, °C
-24
Boiling point, °C
202
Vapor pressure, mmHg
6.5 (25 C)
Vapor density (air=1)
3.4
Saturation Concentration
380 ppm at 20 C (calculated)
Evaporization number
0.06 (butyl acetate = 1)
Critical temperature
451
Critical pressure
47.2
Density
1.033 g/cm3 (20 C)
Solubility in water
Soluble
Viscosity
1.65 cp at 25C
Surface tension
40.7 g/s2
Refractive index
1.4684 (20 C)
Dipole moment
4.1 D(20 C)
Dielectric constant
33 (25 C)
Partition coefficient, pKow
-0.54
Heat of fusion
9.11 kJ/mol
Heat of vaporization
5336 kJ/mol
Heat of combustion
-2994 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Store protected from light.
B3 D2B
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Store protected from light. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation.
Disposal code
5
Stability
Stable at room temperature in closed containers under normal storage and handling conditions. Light sensitive.
Incompatibilities
Strong oxidizing agents, strong acids, sulfur, carbon disulfide, chlorinating agents, moisture.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
91
Autoignition, °C
245
Upper exp. limit, %
9.5
Lower exp. limit, %
1.3
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Combustible Liquid. Toxic oxides of nitrogen may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use extinguishing media most appropriate for the surrounding fire. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Combustible when exposed to heat, open flame, or powerful oxidizers.
Hazards
Contact with metals may evolve flammable hydrogen gas.
Combustion products
Toxic oxides of nitrogen may be formed in fire.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
MAK: 20 ppm; 80 mg/m3; skin (1996).
Poison_Class
5
Exposure effects
Prolonged or repeated skin contact may cause dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
   Inhalation
Causes respiratory tract irritation. May cause abdominal pain, nausea, vomiting, and inflammation of the gums and mouth. Inhalation of vapors in confined spaces or when hot may cause drowsiness, dizziness, headache, nausea, or lung irritation.
   Skin
Causes skin irritation. May be absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin.
   Eyes
Causes moderate eye irritation. May cause temporary corneal clouding.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1760
Response guide
Hazard class
8
Packing Group
I; II; III
 
USCG CHRIS Code
MPY
 
9 Aromatic amines
HS Code
2933 79 00
 
Std. Transport #
4915473
 
IMO Chemical Code
18
IMO Pollution Category
D