N-Methyl-N'-nitro-N-nitrosoguanidine

  • N-Methyl-N-nitroso-N'-nitroguanidine
  • Methylnitronitrosoguanidine
  • 1-Nitro-N-nitroso-N-methylguanidine
  • MNNG
  • 1-Methyl-3-nitro-1-nitrosoguanidine
Formula
C2H5N5O3
Structure
Description
A yellow powder.
Uses
Experimentally as a carcinogen and mutagen. Formerly used in preparation of diazomethane.

Registry Numbers and Inventories.
CAS
70-25-7
EC (EINECS/ELINCS)
200-730-1
EC Index Number
612-083-00-6
EC Class
Carcinogenic Category 2; Harmful; Irritant; Dangerous for the Environment
RTECS
MF4200000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
UN (DOT)
1325
Merck
12,6177
Beilstein/Gmelin
1779490
Beilstein Reference
4-04-00-03366
RCRA
U163
Swiss Giftliste 1
G-5260
Canada DSL/NDSL
NDSL
US TSCA
Listed
New Zealand
Listed

Properties.
Formula
C2H5N5O3
Formula mass
147.09
Melting point, °C
118
Solubility in water
Reacts violently
Partition coefficient, pKow
0.67

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate protective gloves, clothing and goggles.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Keep material dry. Combustion products include corrosive or toxic vapors. Land spill: Cover solids with a plastic sheet to prevent dissolving in rain or fire fighting water.
Stability
Can explode on heating and under high impact. Explosive diazoalkanes are formed upon alkaline hydrolysis.
Incompatibilities
Sensitive to heat Incompatible with acids, bases, oxidizing agents and reducing agents Reacts with bases to release highly toxic, irritating and explosive gases Reacts slowly with acids to release nitrous acid Reacts with various nucleophiles, especially amines and thiols Reacts with aqueous potassium hydroxide to form a highly reactive compound.
Decomposition
When heated to decomposition it emits very toxic fumes of nitrogen oxides.

Fire.
Fire fighting
Use alcohol foam, dry chemical or carbon dioxide.
Fire potential
Flammable/combustible material.
Hazards
May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form. May re-ignite after fire is extinguished.
Combustion products
Fire may produce irritating and/or toxic gases.

Health.
Carcinogin
I-2A, N-2, CP65
Poison_Class
1*
Exposure effects
   Ingestion
See inhalation.
   Inhalation
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
   Skin
May cause burns.
   Eyes
See Skin.

First aid
 
   Ingestion
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1325
Response guide
Hazard class
4.1
Packing Group
II; III
 
USCG CHRIS Code
MNN
 
Std. Transport #
4916723