N-Methylaniline

  • N-Methylbenzenamine
  • Monomethyl aniline
  • Methylphenylamine
Formula
C6H5NHCH3
Structure
Description
Colorless to light viscous liquid with a characteristic odor. Turns brown on exposure to air.
Uses
Organic synthesis, solvent, acid acceptor.

Registry Numbers and Inventories.
CAS
100-61-8
EC (EINECS/ELINCS)
202-870-9
EC Index Number
612-015-00-5
EC Class
Toxic; Danger of cumulative effects; Dangerous for the Environment
R 23/24/25 33 50/53
S 28 36/37 45 60 61
RTECS
BY4550000
RTECS class
Other
UN (DOT)
2294
Merck
12,6098
Beilstein/Gmelin
741982
Beilstein Reference
4-12-00-00241
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H9N
Formula mass
107.16
Melting point, °C
-57
Boiling point, °C
196.3
Vapor pressure, mmHg
0.5 (20 C)
Vapor density (air=1)
3.70
Saturation Concentration
395 ppm (0.04%) at 20 C (calculated)
Critical temperature
428
Critical pressure
51.3
Density
0.989 g/cm3 (20 C)
Solubility in water
Slightly soluble
Viscosity
2.568 cp @ 15C
Surface tension
39.97 g/s2 @ 15 C
Refractive index
1.5702 (20 C)
pKa/pKb
9.15 (pKb)
Partition coefficient, pKow
1.66
Heat of vaporization
42.2 kJ/mol
Heat of combustion
-3314 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store under an inert atmosphere.
B3 D1B D2A
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Provide ventilation. Do not get water inside containers.
Disposal code
9
Stability
Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to air.
Incompatibilities
Strong oxidizing agents, acids, acid chlorides, acid anhydrides.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
79
Autoignition, °C
500
Upper exp. limit, %
7.4
Lower exp. limit, %
1.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible Liquid. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Extinguishing media: Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Toxic vapors are generated when heated.
Health
1
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: TWA 0.5 ppm (2 mg/m3) [skin] OSHA PEL: TWA 2 ppm (9 mg/m3) [skin] IDLH 100 ppm
Exposure effects
May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Prolonged or repeated exposure may cause nausea, dizziness, and headache. Effects may be delayed.
   Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. Effects may be delayed.
   Inhalation
Effects may be delayed. May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
2294
Response guide
Hazard class
6.1
Packing Group
III
 
USCG CHRIS Code
MAN
 
9 Aromatic amines
HS Code
2921 42 90
 
Std. Transport #
4925137