N-Nitrosodiethylamine

  • Diethylamine, N-nitroso
  • Diethylnitrosamine
  • Nitrosodiethylamine
  • N-Nitroso-N,N-diethylamine
  • Nitrous diethylamide
Formula
C4H10N2O
Structure
Description
Clear slightly yellow liquid.
Uses
Gasoline & lubricant additive, antioxidant, stabilizer in plastics.

Registry Numbers and Inventories.
CAS
55-18-5
EC (EINECS/ELINCS)
200-226-1
RTECS
IA3500000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
Merck
12,6734
Beilstein/Gmelin
1744991
Beilstein Reference
4-04-00-03386
RCRA
U174
Swiss Giftliste 1
G-5268
Canada DSL/NDSL
DSL
US TSCA
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C4H10N2O
Formula mass
102.13
Boiling point, °C
177
Vapor pressure, mmHg
0.9
Density
0.951 g/cm3 (18 C)
Solubility in water
Very soluble
Surface tension
32.81 g/s2 (20 C)
Refractive index
1.43535 (19.9 C)
Partition coefficient, pKow
0.48

Hazards and Protection.
Storage
Light-sensitive, especially to ultraviolet light, should be stored in dark bottles.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable at room temperature for several days in aqueous solution @ neutral and alkaline ph; less stable @ strongly acid pH @ room temperature.
Incompatibilities
Reacts with strong oxidizing agents Incompatible with reducing agents.

Fire.
Flash Point,°C
61
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This chemical is combustible.

Health.
Carcinogin
I-2A, N-2, CP65
Poison_Class
1*
Exposure effects
Seizures, cerebral edema, headache, and malaise have been reported. Fetal death, fetotoxicity, and other teratogenic effects were observed in rat and mouse studies. Pre- and post-implantation mortality and abortion were observed in rats. Abnormal changes in sperm morphology were detected in mice.
   Ingestion
Vomiting, gastrointestinal hemorrhage, and peritonitis have occurred.
   Inhalation
Pulmonary edema, congestion, and hemorrhagic areas have been reported.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
NDE