N-Nitrosodiphenylamine

  • Curetard a
  • Delac j
  • Diphenylnitrosamine
  • N,N-Diphenylnitrosamine
  • Diphenyl n-Nitrosoamine
  • Naugard tjb
Formula
C12H10N2O
Structure
Description
Yellow to brown or orange powder or flakes or a black solid.
Uses
N-nitrosodiphenylamine is an effective radical scavenger, and can be used to stabilize monomers, polymers, and petroleum products. In rubber processing, its major use is believed to be as an anti-scorching agent, or vulcanization retarder, during rubber compounding.

Registry Numbers and Inventories.
CAS
86-30-6
EC (EINECS/ELINCS)
201-663-0
RTECS
JJ9800000
RTECS class
Tumorigen; Mutagen; Primary Irritant
Beilstein/Gmelin
909531
Beilstein Reference
4-16-00-00865
RCRA
K022
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C12H10N2O
Formula mass
198.22
Melting point, °C
63 - 65
Boiling point, °C
347
Vapor pressure, mmHg
6E-5 (25 C)
Density
1.251 g/cm3
Solubility in water
10 mg/L (25 C)
Partition coefficient, pKow
3.13
Heat of vaporization
59.1 kJ/mol
Heat of combustion
-6418 kJ/mol

Hazards and Protection.
Storage
Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Gloves which are impermeable should be worn. Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
The nitrosamines are stable at neutral pH. Nitrosamines.
Incompatibilities
Sensitive to moisture at elevated temperatures in strongly acidic solutions May react vigorously with oxidizing agents.

Fire.
Flash Point,°C
163
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Carcinogin
CP65
Exposure effects
Seizures, cerebral edema, headache, and malaise have been reported. Fetal death, fetotoxicity, and other teratogenic effects were observed in rat and mouse studies. Pre- and post-implantation mortality and abortion were observed in rats. Abnormal changes in sperm morphology were detected in mice.
   Ingestion
Vomiting, gastrointestinal hemorrhage, and peritonitis have occurred.
   Inhalation
Pulmonary edema, congestion, and hemorrhagic areas have been reported.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
NPA