N-Nitrosodipropylamine

  • Dipropylnitrosamine
  • di-N-Propylnitrosamine
  • N-Nitroso-N-propyl-1-propanamine
  • Propanamine, N-nitroso-N-propyl
  • 1-Propanamine, N-nitroso-N-propyl
  • Propylamine, N-nitroso-N-di
Formula
C6H14N2O
Structure
Description
Clear to pale yellow liquid.
Uses
N-nitroso compounds are produced primarily as research chemicals and not for commercial purposes. N-nitroso compounds.

Registry Numbers and Inventories.
CAS
621-64-7
EC (EINECS/ELINCS)
210-698-0
EC Index Number
612-098-00-8
EC Class
Carcinogenic Category 2; Harmful; Dangerous for the Environment
RTECS
JL9700000
RTECS class
Tumorigen; Mutagen; Reproductive Effector
Beilstein/Gmelin
1752621
Beilstein Reference
4-04-00-03388
RCRA
U111
Swiss Giftliste 1
G-5265
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C6H14N2O
Formula mass
130.18
Boiling point, °C
206
Density
0.931 g/cm3 (0 C)
Solubility in water
soluble
Surface tension
31.69 g/s2 (19 C)
Refractive index
1.44161 (20 C)
Partition coefficient, pKow
1.360

Hazards and Protection.
Storage
Store at the containers described in field strg in a locked solvent storage cabinet, deep freeze, or safety refrigerator. Avoid exposure to light and moisture.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Nonexplosive. The vapor probably does not form an explosive mixture with air at ordinary temperatures.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire.
Flash Point,°C
98
Fire fighting
A fire in your laboratory involving this chemical may produce dangerous vapors. Please evacuate the area immediately. As a firefighter, you should be equipped with full-body protective clothing and a self-contained breathing apparatus. You should extinguish this fire with a dry chemical, carbon dioxide or halon extinguisher. You should avoid using a water or foam extinguisher as they may cause spattering.

Health.
Carcinogin
I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
Seizures, cerebral edema, headache, and malaise have been reported. Fetal death, fetotoxicity, and other teratogenic effects were observed in rat and mouse studies. Pre- and post-implantation mortality and abortion were observed in rats. Abnormal changes in sperm morphology were detected in mice.
   Ingestion
Vomiting, gastrointestinal hemorrhage, and peritonitis have occurred.
   Inhalation
Pulmonary edema, congestion, and hemorrhagic areas have been reported.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
DYT