N-Nitrosomorpholine

  • Morpholine, 4-nitroso
  • Mitrosomorpholine
  • 4-Nitrosomorpholine
Formula
C4H8N2O2
Structure
Description
Yellow crystals.
Uses
Solvent for polyacrylonitrile & chemical intermediate in synthesis of n-aminomorpholine.

Registry Numbers and Inventories.
CAS
59-89-2
RTECS
QE7525000
RTECS class
Tumorigen; Mutagen
Merck
12,6738
Beilstein/Gmelin
112139
Beilstein Reference
4-27-00-00627
Swiss Giftliste 1
G-5282
New Zealand
Listed

Properties.
Formula
C4H8N2O2
Formula mass
116.12
Melting point, °C
29
Boiling point, °C
224
Vapor pressure, mmHg
0.13 (pKb)
Density
1.104 g/cm3 (20 C)
Solubility in water
Very soluble
Refractive index
1.4925 (20 C)
pKa/pKb
12.41 (pKb)
Partition coefficient, pKow
-0.44
Heat of vaporization
44.4 kJ/mol
Heat of combustion
-2581 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
Stable @ room temperature for more than 14 days in neutral and alk aqueous solution in dark; slightly less stable in acidic solution. Light-sensitive, esp to UV light; photochemically reactive.
Incompatibilities
Incompatible with strong oxidizing agents.

Fire.
Flash Point,°C
91
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
Fire potential
This material is probably combustible.

Health.
Carcinogin
I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
   Ingestion
Irritation of the gastrointestinal tract is likely after exposure to morpholine. The amount of irritation is dependent upon the concentration.
   Inhalation
Cough and nasal irritation have been seen in humans exposed to 1200 ppm for about 1.5 Minutes.
   Skin
Skin contact represents a moderate degree of hazard, which decreases as the concentration decreases to 25% or less in water.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
USCG CHRIS Code
NMO