- Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-(S)
White crystalline flakes or yellow oil that solidifies on standing in the cold.
No evidence was found that n-nitrosonornicotine has any uses other than as a laboratory chemical.
Registry Numbers and Inventories.
Melting point, °C
Boiling point, °C
Vapor pressure, mmHg
3E-5 (25 C)
Solubility in water
Partition coefficient, pKow
Heat of vaporization
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
Fire may produce irritating, corrosive and/or toxic gases.
I-2B, N-2, CP65
Elevated blood pressure, rapid heart rate and rapid breathing may occur, followed by abnormally low blood pressure, low heart rate and bradypnea. Respiratory stimulation is one of the principal signs of nicotine poisoning. High doses can produce fatal respiratory depression of both central and peripheral origin. Headache, dizziness, restlessness followed by lethargy, coma and seizures may occur. Initial excitation and agitation may be followed by lethargy progressing to coma. Headache, agitation, tremor and at higher doses, CNS and neuromuscular depression and seizures have all been reported. Nicotine is a possible human teratogen. <br>Nicotine is teratogenic in mice but not in several other species. It crosses the placenta and is excreted in breast milk. It has reduced fertility in male and female rats.
Nicotine initially causes a burning sensation in mouth, throat, esophagus and stomach. Increased salivation follows. Nausea, vomiting, abdominal pain, and diarrhea are common. Vomiting may occur very early after tobacco ingestion, minimizing absorption and other toxic manifestations.
Initial tachypnea, followed by dyspnea is common. Late bradypnea may occur. Increased bronchial secretions, a cholinergic effect, are common. Respiratory tract irritation may occur. Respiratory failure with apnea may occur following large ingestions and may occur quickly (5 minutes postingestion).
Intense sweating may be noted. Dermatosis may develop with chronic exposure.
Increased salivation and tearing may occur. Initial constriction of the pupil followed by prolonged dialation of the pupils may occur. Burning sensation in mouth and throat may occur. Gingival recession has been observed after long-term oral use of smokeless snuff.
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
I; II; III