N-Nitrosonornicotine

  • 1'-Dimethyl-1'-nitrosonicotine
  • N'-Nitrosonornicotine
  • 1-Nitroso-2-(3-pyridyl)pyrrolidine
  • 3-(1-Nitroso-2-pyrrolidinyl)pyridine
  • Pyridine, 3-(1-nitroso-2-pyrrolidinyl)-(S)
Formula
C9H11N3O
Structure
Description
White crystalline flakes or yellow oil that solidifies on standing in the cold.
Uses
No evidence was found that n-nitrosonornicotine has any uses other than as a laboratory chemical.

Registry Numbers and Inventories.
CAS
16543-55-8
RTECS
QS6550000
RTECS class
Tumorigen; Mutagen
UN (DOT)
1655
Beilstein/Gmelin
10269
Beilstein Reference
5-23-06-00072

Properties.
Formula
C9H11N3O
Formula mass
177.23
Melting point, °C
47
Boiling point, °C
370
Vapor pressure, mmHg
3E-5 (25 C)
Solubility in water
Soluble
pKa/pKb
8.84 (pKb)
Partition coefficient, pKow
-0.08
Heat of vaporization
59.2 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Respirators
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability
No data.
Incompatibilities
Incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides.

Fire.
Flash Point,°C
177
Fire fighting
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.
Fire potential
Non-Combustible
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-2B, N-2, CP65
Exposure effects
Elevated blood pressure, rapid heart rate and rapid breathing may occur, followed by abnormally low blood pressure, low heart rate and bradypnea. Respiratory stimulation is one of the principal signs of nicotine poisoning. High doses can produce fatal respiratory depression of both central and peripheral origin. Headache, dizziness, restlessness followed by lethargy, coma and seizures may occur. Initial excitation and agitation may be followed by lethargy progressing to coma. Headache, agitation, tremor and at higher doses, CNS and neuromuscular depression and seizures have all been reported. Nicotine is a possible human teratogen. <br>Nicotine is teratogenic in mice but not in several other species. It crosses the placenta and is excreted in breast milk. It has reduced fertility in male and female rats.
   Ingestion
Nicotine initially causes a burning sensation in mouth, throat, esophagus and stomach. Increased salivation follows. Nausea, vomiting, abdominal pain, and diarrhea are common. Vomiting may occur very early after tobacco ingestion, minimizing absorption and other toxic manifestations.
   Inhalation
Initial tachypnea, followed by dyspnea is common. Late bradypnea may occur. Increased bronchial secretions, a cholinergic effect, are common. Respiratory tract irritation may occur. Respiratory failure with apnea may occur following large ingestions and may occur quickly (5 minutes postingestion).
   Skin
Intense sweating may be noted. Dermatosis may develop with chronic exposure.
   Eyes
Increased salivation and tearing may occur. Initial constriction of the pupil followed by prolonged dialation of the pupils may occur. Burning sensation in mouth and throat may occur. Gingival recession has been observed after long-term oral use of smokeless snuff.

First aid
 
   Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
   Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
   Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
   Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Transport.
UN number
1655
Response guide
Hazard class
6.1
Packing Group
I; II; III