N-Nitrososarcosine

  • n-Methyl-n-(carboxymethyl)nitrosamine
  • n-Methyl-n-nitrosoglycine
  • n-Nitrosomethylglycine
  • NSAR
Formula
C3H6N2O3
Structure
Description
Pale-yellow crystals.

Registry Numbers and Inventories.
CAS
13256-22-9
RTECS
VQ3150000
RTECS class
Tumorigen; Mutagen
Beilstein/Gmelin
1756162
Beilstein Reference
0-04-00-00380
Swiss Giftliste 1
G-5283

Properties.
Formula
C3H6N2O3
Formula mass
118.11
Melting point, °C
75 - 77
Solubility in water
miscible in all prop

Hazards and Protection.
Storage
Storage location should be close to laboratory where it is to be used, so that only small amounts need to be transported. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Dispensers of liquid detergent should be available. In the laboratory, gloves and protective clothing should always be worn but should not be assumed to provide full protection. Carefully fitted masks or respirators may be necessary when working with particulates or gases, and disposable plastic aprons might provide additional protection. Protective clothing should be of distinctive color, as a reminder not to be worn outside the laboratory.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Free acid is unstable in aqueous solution; concentration decrease of more than 10% in 24 hours has been observed light-sensitive, esp to UV light.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2B, N-2, CP65
Poison_Class
1*
Exposure effects
Mild central nervous system depression or excitation may occur after ingestion or vapor inhalation. CNS effects can occur secondary to hydrocarbon pneumonitis and hypoxia, or from additives and contaminants (aniline, heavy metals, camphor, or pesticides). Some hydrocarbons are simple asphyxiants (e.G., Methane, ethane, propane gasses) which can produce CNS effects secondary to hypoxia. In a prospective study in Toronto, major congenital malformations were noted in 13 of 125 fetuses of mothers exposed to organic solvents during pregnancy.
   Ingestion
Nausea, vomiting, diarrhea, and abdominal pain may occur following ingestion.
   Inhalation
Coughing, choking, tachypnea, dyspnea, cyanosis, rales, hemoptysis, pulmonary edema, pneumatoceles, lipoid pneumonia, or respiratory arrest may develop following ingestion and aspiration.

First aid
 
   Ingestion
Pure petroleum distillates - gastric decontamination is not indicated in the majority of accidental ingestions, since systemic toxicity is unlikely from a pure petroleum distillate. Other hydrocarbons - gastric decontamination may be indicated if a large amount of a toxic hydrocarbon has been ingested (e.G., Suicide attempt) and if spontaneous vomiting has not occurred. Decontamination may also be indicated for ingestions of highly toxic hydrocarbons (e.G., Halogenated hydrocarbons, carbon tetrachloride) and for hydrocarbons which contain very toxic additives (e.G., Heavy metals, pesticides). The decision to decontaminate should be based on the toxicity of the agent, the volume ingested, time of ingestion and patient's clinical status. The potential for rapid cns depression, with seizures and/or respiratory depression, must be considered.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists. Some chemicals can produce systemic poisoning by absorption through intact skin. Carefully observe patients with dermal exposure for the development of any systemic signs or symptoms and administer symptomatic treatment as necessary.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.