N,N-Dimethylformamide

  • Dimethylformamide
  • DMF
  • DMFA
Formula
HCON(CH3)2
Structure
Description
Colorless to slightly yellow liquid with a fishy, unpleasant odor.
Uses
Solvent.

Registry Numbers and Inventories.
CAS
68-12-2
EC (EINECS/ELINCS)
200-679-5
EC Index Number
616-001-00-X
EC Class
Toxic for reproduction Category 2; Harmful; Irritant
R 61 20/21 36
RTECS
LQ2100000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Primary Irritant
UN (DOT)
2265
Merck
13,3269
Beilstein/Gmelin
605365
Beilstein Reference
4-04-00-00171
EPA OPP
366200
Swiss Giftliste 1
G-1559
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C3H7NO
Formula mass
73.10
Melting point, °C
-61
Boiling point, °C
153
Decomposition point, °C
350
Vapor pressure, mmHg
2.3 (20 C)
Vapor density (air=1)
2.5
Saturation Concentration
12 g/m3 at 20 C
Evaporization number
0.17 (butyl acetate=1)
Odor Threshold Odor threshold 300 mg/m3
Critical temperature
374
Critical pressure
44.2
Density
0.949 g/cm3 (20 C)
Solubility in water
Miscible
Viscosity
0.82 cp @ 20C
Surface tension
35.2 g/s2 @ 25 C
Refractive index
1.42803 (20 C)
Dipole moment
3.8 D (20 C)
Dielectric constant
36.7 (20 C)
Partition coefficient, pKow
-1.01
Heat of fusion
8.05 kJ/mol
Heat of vaporization
47.0 kJ/mol
Heat of combustion
-1915 kJ/mol

Hazards and Protection.
Storage
Protect against physical damage. Store in a cool, dry well-ventilated location, away from any area where the fire hazard may be acute. Outside or detached storage is preferred. Separate from incompatibles. Containers should be bonded and grounded for transfers to avoid static sparks. Storage and area should be No Smoking areas.
B3 D2B
Handling
Wash thoroughly after handling. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Do not breathe dust, vapor, mist, or gas. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not ingest or inhale. Use with adequate ventilation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Do not flush into a sewer. Clean up spills immediately, using the appropriate protective equipment. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Provide ventilation.
Disposal code
1
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Bromine, carbon tetrachloride, chromic anhydride, 2,5-dimethylpyrrole, phosphorus oxychloride, hexachlorobenzene, magnesium nitrate, methylene diisocyanate, phosphorus trioxide, triethyl aluminum, organic nitrates, acidic and alkaline materials, and other halogenated compounds. Contact with iron or strong oxidizers may cause fires and explosions; may react violently with alkyl aluminums. Methylene diisocyanate can polymerize violently on contact with DMF.
Decomposition
May form ammonia, carbon oxides, amines, and nitrogen oxides when heated to decomposition. Above 350C, DMF begins to degrade with formation of dimethylamine and carbon monoxide.

Fire.
Flash Point,°C
58
Autoignition, °C
410
Upper exp. limit, %
16
Lower exp. limit, %
2.2
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Extinguishing media: Use water spray to cool fire-exposed containers. Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Fire potential
Flammable liquid and vapor.
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Containers may explode when heated.
Combustion products
During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Health
2
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
NIOSH REL: TWA 10 ppm (30 mg/m3) [skin] OSHA PEL: TWA 10 ppm (30 mg/m3) [skin] IDLH 500 ppm
Poison_Class
3
Exposure effects
Repeated skin contact may cause dermatitis. Repeated or prolonged exposure to vapors may cause damage to the liver and kidney.
   Ingestion
Causes irritation to the gastrointestinal tract. Symptoms parallel inhalation. Fatal dose estimated at 10 g.
   Inhalation
Causes irritation to respiratory tract. Symptoms may include coughing, shortness of breath. Causes liver, kidney, cardiovascular system and central nervous system disorders. May cause abdominal pain, loss of appetite, nausea, weakness, dizziness, headache, constipation, vomiting, diarrhea, increased blood pressure anxiety, and palpitations. A flushing of the face and skin may occur, especially with coincident ingestion of alcoholic beverages.
   Skin
Causes irritation to skin. Symptoms include redness, itching and pain. Can cause skin problems. Absorption through the skin can readily occur, resulting in symptoms paralleling inhalation.
   Eyes
Causes irritation, redness, and pain. May cause severe irritation and blurred vision.

First aid
 
   Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Induce vomiting by giving one teaspoon of Syrup of Ipecac.
   Inhalation
Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
2265
Response guide
Hazard class
3
Packing Group
III
 
USCG CHRIS Code
DMF
 
HS Code
2924 19 00
 
Std. Transport #
4909135
 
IMO Chemical Code
17
IMO Pollution Category
D
IMO Hazard code
S