Nalbuphine

  • 17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol
  • Cyclobutylmethyldihydromorphine A
  • N-Cyclobutylmethyl-14-hydroxydihydronormorphine
Formula
C21H27NO4
Structure
Description
Odorless, white powder.
Uses
Opiod agonist/antagonist analgesic.

Registry Numbers and Inventories.
CAS
20594-83-6
EC (EINECS/ELINCS)
243-901-6
Merck
12,6444

Properties.
Formula
C21H27NO4
Formula mass
357.45
Melting point, °C
227 - 232
Vapor pressure, mmHg
1.1E-13 (25 C)
Density
1.44 g/cm3 (20 C)
Solubility in water
Soluble
pKa/pKb
6.65 (pKa)
Partition coefficient, pKow
1.79

Hazards and Protection.
Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect from physical damage and direct sunlight.
Protection
Wear protective gloves and clean body-covering clothing. Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area.
Respirators
For conditions of use where exposure to dust or mist is apparent and engineering controls are not feasible, a particulate respirator (NIOSH type N95 or better filters) may be worn. If oil particles (e.g. lubricants, cutting fluids, glycerine, etc.) are present, use a NIOSH type R or P filter. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres.
Small spills/leaks
Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container.
Stability
Stable under ordinary conditions of use and storage.
Incompatibilities
Strong oxidizers.

Fire.
Fire fighting
Wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. Extinguish with water spray, dry chemical, alcohol foam, or carbon dioxide.
Fire potential
As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Hazards
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Produces acute withdrawal symptoms in individuals physically dependent on opiods. Persons with impaired kidney or liver function may be more susceptible to the effects of the substance.
   Ingestion
Narcotic antagonist. Although not considered highly toxic, the acute toxic syndrome in non-opiod dependent subjects is not well defined. May produce constricted pupils. Large doses may cause liver damage.
   Inhalation
Inhalation of dust may cause irritation to the respiratory tract.
   Skin
Not expected to cause any adverse health effects.
   Eyes
No adverse effects expected but dust may cause mechanical irritation.

First aid
 
   Ingestion
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person.
   Inhalation
Remove to fresh air. Get medical attention for any breathing difficulty.
   Skin
Wash exposed area with soap and water. Get medical advice if irritation develops.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Transport.