Naproxen

  • axer
  • bonyl
  • Calosen
  • Cg 3117
  • Diocodal
  • Dysmenalgit n
Formula
C14H14O3
Structure
Description
Crystals from acetone-hexane. Practically odorless.
Uses
anti-inflammatory drug

Registry Numbers and Inventories.
CAS
22204-53-1
EC (EINECS/ELINCS)
244-838-7
R 22 36/37/38
S 26 36/37/39
RTECS
UF5275000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,6504
Beilstein/Gmelin
3591067
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C14H14O3
Formula mass
230.26
Melting point, °C
156
Boiling point, °C
404
Vapor pressure, mmHg
3E-7 (25 C)
Solubility in water
Insoluble
pKa/pKb
4.15 (pKa)
Partition coefficient, pKow
3.24
Heat of fusion
31.73 kJ/mol
Heat of vaporization
69.1 kJ/mol

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Flash Point,°C
155
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen. Naproxen is pregnancy category B. <br>&nbsp;&nbsp;&nbsp;1. Risk Factor D if used in 3rd trimester or near delivery. <br>Because of known effects of the fetus (closure of ductus arteriosus), it should be avoided during late pregnancy. <br>Naproxen has been found in the milk of lactating women; however, The American Academy of Pediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998).
   Inhalation
Apnea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing.
   Skin
Photosensitivity and pseudoporphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.