Nebularine

  • Purine 9-b-D-ribofuranoside
  • 9-b-D-Ribofuranosyl-9H-purine
  • Purinosine
  • Ribosylpurine
Formula
C10H12N4O4
Structure
Uses
Used to introduce degenerate sites within oligonucleotides, nebularine exhibits low, but unequal, hydrogen bonding to all four bases.

Registry Numbers and Inventories.
CAS
550-33-4
EC (EINECS/ELINCS)
208-981-9
36/37/38
RTECS
UO9100000
RTECS class
Drug
Merck
12,6521
Beilstein/Gmelin
91539
Beilstein Reference
4-26-00-01740
New Zealand
Listed

Properties.
Formula
C10H12N4O4
Formula mass
252.23
Melting point, °C
174 - 177
Boiling point, °C
592
Vapor pressure, mmHg
8E-15 (25 C)
Solubility in water
Very soluble
pKa/pKb
12.17 (pKb)
Heat of vaporization
92.8 kJ/mol

Hazards and Protection.
Protection
Wear appropriate government approved respirator, chemical-resistant gloves, safety goggles, other protective clothing.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
312
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
The chemical, physical, and toxicological properties of this product have not been thoroughly investigated. Exercise due care.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.