Niclosamide

  • Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy
  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
  • 2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
  • 2-Hydroxy-5-chloro-n-(2-chloro-4-nitrophenyl)benzamide
  • 2',5-Dichloro-4'-nitrosalicylanilide
Formula
C13H8Cl2N2O4
Structure
Description
Pale, yellow crystals.
Uses
Medication, molluscicide.

Registry Numbers and Inventories.
CAS
50-65-7
EC (EINECS/ELINCS)
200-056-8
RTECS
VN8400000
RTECS class
Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector
Merck
12,6602
Beilstein/Gmelin
2820605
EPA OPP
217800
Swiss Giftliste 1
G-1539
Austrailia AICS
Listed
New Zealand
Listed

Properties.
Formula
C13H8Cl2N2O4
Formula mass
327.12
Melting point, °C
225-230
Solubility in water
5-8 mg/L at 20 C
Partition coefficient, pKow
10 @ pH 9.6

Hazards and Protection.
Storage
Stored at a temperature less than 30C; freezing of the tablets should be avoided.
Handling
Avoid eye and skin contact. Do not smoke or eat while using. Wear eye protection (face visor or goggles) if accidental eye contact can occur. Observe good personal hygiene. Avoid breathing dust.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Sweep or vacuum. Place in bag and dispose of waste in compliance with local waste disposal regulations. Ventilate area and wash spill site after material pick-up is complete.
Stability
Tablets are sensitive to moisture. Decomposes more rapidly in the presence of UV irradiation. It is stable to heat and is hydrolysed by concentrated acid or alkali.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Poison_Class
4
Exposure effects
   Ingestion
May cause nausea, vomiting, abdominal pain, taste disturbances, fatigue, headache, confusion, insomnia, dizziness, fever, an influenza-like syndrome, arthralgia, muscle pain, hypotension, vasculitis and skin rash.
   Inhalation
Not considered hazardous under normal conditions of use. May cause same health side effects as when swallowed.
   Skin
Not considered hazardous under normal conditions of use. Contact may cause skin irritation.
   Eyes
Contact may cause temporary stinging or redness.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.