Nicotine hydrochloride

  • Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, hydrochloride, (S)
Formula
C10H14N2.xClH
Structure
Description
A white crystalline solid.

Registry Numbers and Inventories.
CAS
2820-51-1
RTECS
QS8575000
RTECS class
Other
UN (DOT)
1656
Beilstein/Gmelin
4010136
Beilstein Reference
5-23-06-00064
RCRA
P075

Properties.
Formula
C10H14N2*ClH
Formula mass
417.48
Solubility in water
Very soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear full protective clothing and self-contained breathing apparatus. Equipment should be resistant to hydrochloric acid vapors.
Respirators
Wear positive pressure self-contained breathing apparatus (SCBA).
Small spills/leaks
Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.
Stability
Moderate when exposed to heat or flame. Reactive at high temperature or pressure.

Fire.
Fire fighting
Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide.
Fire potential
Moderate when exposed to heat or flame.
Hazards
Containers may explode when heated. Runoff may pollute waterways.
Combustion products
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Health.
Exposure effects
   Ingestion
Nicotine initially causes a burning sensation in mouth, throat, esophagus and stomach. Increased salivation follows. Nausea, vomiting, abdominal pain, and diarrhea are common. Vomiting may occur very early after tobacco ingestion, minimizing absorption and other toxic manifestations.
   Inhalation
Initial tachypnea, followed by dyspnea is common. Late bradypnea may occur. Increased bronchial secretions, a cholinergic effect, are common. Respiratory tract irritation may occur. Respiratory failure with apnea may occur following large ingestions and may occur quickly (5 minutes postingestion).
   Skin
Intense sweating may be noted. Dermatosis may develop with chronic exposure.
   Eyes
See Inhalation.

First aid
 
   Ingestion
Emesis is usually spontaneous. Since rapid onset of seizures may occur, ipecac-induced vomiting is not advised.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
UN number
1656
Response guide
Hazard class
6.1
Packing Group
II
 
Std. Transport #
4921448