Nicotine

  • 3-(1-methyl-2-pyrrolidinyl)pyridine
  • (S)-3-(1-Methylpyrrolidin-2-yl)pyridine
  • 1-Methyl-2-(3-pyridyl)pyrrolidine
  • beta-Pyridyl-alpha-n-methylpyrrolidine
Formula
C10H14N2
Structure
Description
Colorless to pale yellow, oily liquid, turns brown on exposure to air and light. Develops fish-like odor when warm. Hygrosopic.
Uses
Insecticide (former use), fumigant (former use).

Registry Numbers and Inventories.
CAS
54-11-5
EC (EINECS/ELINCS)
200-193-3
EC Index Number
614-001-00-4
EC Class
Very toxic; Toxic; Dangerous for the Environment
R 25 27 51/53
S 36/37 45 61
RTECS
QS5250000
RTECS class
Agricultural Chemical and Pesticide; Mutagen; Reproductive Effector; Human Data; Natural Product
UN (DOT)
1654
Merck
12,6611
Beilstein/Gmelin
82109
Beilstein Reference
5-23-06-00064
RCRA
P075
EPA OPP
56702
Swiss Giftliste 1
G-2057
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C10H14N2
Formula mass
162.24
Melting point, °C
-79
Boiling point, °C
247
Vapor pressure, mmHg
0.03 (25 C)
Vapor density (air=1)
5.61
Saturation Concentration
56 ppm (0.0056%) at 20 C (calculated)
Density
1.01 g/cm3 (25 C)
Solubility in water
Soluble
Surface tension
38.61 g/s2
Refractive index
1.5282 (20 C)
pKa/pKb
6.00 (pKb)
Partition coefficient, pKow
1.17
Heat of vaporization
48.1 kJ/mol
Heat of combustion
-5910 kJ/mol

Hazards and Protection.
Storage
Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear impervious gloves. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Avoid runoff into storm sewers and ditches which lead to waterways. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite.
Disposal code
9
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities
Strong acids, strong oxidizers.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Fire.
Flash Point,°C
101
Autoignition, °C
240
Upper exp. limit, %
4
Lower exp. limit, %
0.7
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing.
Fire potential
Slightly flammable. Flammable if preheated.
Hazards
There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, it emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.
Combustion products
When heated, emits highly toxic fumes.
Health
3
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 0.5 mg/m3 (as TWA) (skin) (ACGIH 1996). MAK: 0.07 ppm; 0.5 mg/m3; H (1996). OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: TWA 0.5 mg/m3 skin NIOSH IDLH: 5 mg/m3
Poison_Class
1
Exposure effects
May cause digestive tract and cardiac disturbances.
   Ingestion
May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death. Exposure causes initial nervous system stimulation followed by severe CNS depression. May cause ataxia and
   Inhalation
May cause effects similar to those described for ingestion.
   Skin
May cause skin irritation. May be fatal if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
1654
Response guide
Hazard class
6.1
Packing Group
II
 
USCG CHRIS Code
NIC
 
HS Code
2939 99 90
 
Std. Transport #
4921785 4925274