Nifedipine

  • Cardifen
  • Calcigard
  • Adalat
  • Procardia XL
  • Dimethyl 4-(o-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
Formula
C17H18N2O6
Structure
Description
Odorless yellow crystals or powder. Tasteless.
Uses
Used to treat high blood pressure by relaxing blood vessels.

Registry Numbers and Inventories.
CAS
21829-25-4
EC (EINECS/ELINCS)
244-598-3
RTECS
US7975000
RTECS class
Drug; Reproductive Effector; Human Data
Merck
12,6617
Beilstein/Gmelin
497773
Beilstein Reference
5-22-04-00268
Canada DSL/NDSL
DSL
Austrailia AICS
Listed
New Zealand
Listed
Korea ECL
Listed

Properties.
Formula
C17H18N2O6
Formula mass
346.34
Melting point, °C
172 - 174
Boiling point, °C
475
Vapor pressure, mmHg
3E-9
Solubility in water
Insoluble
pKa/pKb
10.07 (pKb)
Partition coefficient, pKow
3.17
Heat of fusion
37.0 kJ/mol
Heat of vaporization
72.9 kJ/mol

Hazards and Protection.
Storage
Store in a tightly closed container. Refrigerator (approx 4 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Nitrogen oxides, carbon monoxide, carbon dioxide.

Fire.
Flash Point,°C
240
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. May cause irritation of the digestive tract.
   Inhalation
May cause respiratory tract irritation. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.