Niflumic acid

  • Actol
  • 2-[3-(Trifluoromethyl)anilino]nicotinic acid
  • 2-(a,a,a-Trifluoro-m-toluidino)nicotinic acid
  • 2-[3-(Trifluoromethyl)phenylamino]nicotinic acid
  • 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid
Formula
C13H9F3N2O2
Structure
Uses
Selective cyclooxygenase-2 (COX-2) inhibitor.

Registry Numbers and Inventories.
CAS
4394-00-7
EC (EINECS/ELINCS)
224-516-2
20/21/22 36/37/38
RTECS
QT2999100
RTECS class
Drug; Reproductive Effector
Merck
12,6620
Beilstein/Gmelin
489360
Beilstein Reference
5-22-13-00598
Austrailia AICS
Listed
Korea ECL
Listed

Properties.
Formula
C13H9F3N2O2
Formula mass
282.22
Melting point, °C
204
Boiling point, °C
378
Vapor pressure, mmHg
2E-6 (25 C)
Solubility in water
Slightly soluble
pKa/pKb
1.68 (pKa)
Heat of vaporization
66.0 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store in a cool dry place.
Protection
Rubber gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen fluoride.

Fire.
Flash Point,°C
182
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin.
   Inhalation
Material is irritating to mucous membranes and upper respiratory tract.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Transport.