Nigericin

  • Antibiotic K 178
  • Antibiotic X 464
  • Azalomycin M
  • Helixin C
  • Polyetherin A
  • Stereoisomer of tetrahydro-6-[[9-methoxy-2,4,10-trimethyl-2-[octahydro-2,3'-dimethyl-5'-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-1,6-dioxaspiro[4.5]dec-7-yl]methyl]-a,3-dimethyl-2H-pyran-2-acetic acid
Formula
C40H68O11

Registry Numbers and Inventories.
CAS
28380-24-7
RTECS
QT6825000
Merck
12,6633
Beilstein/Gmelin
1696755

Properties.
Formula
C40H68O11
Formula mass
724.97
Density
1.19 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
4.39 (pKa)
Partition coefficient, pKow
4.82

Hazards and Protection.
Storage
Store at 4 C. desiccate.
Protection
PVC or other plastic material gloves. Safety glasses with side-shields.
Small spills/leaks
Eliminate all ignition sources. Absorb and/or contain spill with inert materials (e.g., sand, vermiculite). Then place in appropriate container. For large spills, use water spray to disperse vapors, flush spill area. Prevent runoff from entering waterways or sewers.
Stability
Stable under recommended storage conditions.
Incompatibilities
Oxidizing and spontaneously flammable materials.

Fire.
Fire fighting
Use dry chemical, CO2, water spray or alcohol foam to extinguish. Wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Water mist may be used to cool closed containers.
Combustion products
Burning produces irritant fumes.
Health
1
 
Flammability
1
 
 
Reactivity
0
 

Health.
Exposure effects
Chronic exposure may cause nausea and vomiting, higher exposure causes unconsciousness.
   Ingestion
May be harmful if swallowed.
   Inhalation
May cause irritation of respiratory tract.
   Skin
May cause skin irritation and/or dermatitis.
   Eyes
Avoid contact with eyes.

First aid
 
   Ingestion
Do not induce vomiting without medical advice.
   Inhalation
Move to fresh air. Call a physician immediately.
   Skin
Rinse immediately with plenty of water and seek medical advice.
   Eyes
In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Transport.