Nigrin

  • Bruneomycin
  • Streptonigrin
  • Rufocromomycin
  • 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid
Formula
C25H22N4O8
Structure
Uses
An aminoquinone antitumour antibiotic.

Registry Numbers and Inventories.
CAS
3930-19-6
EC (EINECS/ELINCS)
223-501-8
53 36/37/39 45
RTECS
TJ7350000
RTECS class
Drug; Mutagen; Reproductive Effector; Natural Product
UN (DOT)
3172
Merck
12,8986
Beilstein/Gmelin
599390
Beilstein Reference
5-25-17-00308

Properties.
Formula
C25H22N4O8
Formula mass
506.47
Melting point, °C
301 - 303
Vapor pressure, mmHg
9E-23 (25 C)
pKa/pKb
3.66 (pKa)
Heat of vaporization
112.7 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Fire potential
Combustible material: may burn but does not ignite readily.
Hazards
Emits toxic fumes under fire conditions.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.
Health
4
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Very toxic if swallowed. Target organ(s): Bone marrow.
   Ingestion
May be fatal if swallowed.
   Inhalation
Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.
UN number
3172
Response guide
Hazard class
6.1
Packing Group
I