Nitrendipine

  • Nidrel
  • Bayotensin
  • Baypress
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester
  • Ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
Formula
C18H20N2O6
Structure
Description
Yellow to green powder.
Uses
Ca channel blocker; anti-hypertensive.

Registry Numbers and Inventories.
CAS
39562-70-4
EC (EINECS/ELINCS)
254-513-1
20/21/22
RTECS
US5653000
RTECS class
Drug; Reproductive Effector
Merck
12,6669
Beilstein/Gmelin
498823
Beilstein Reference
6-22

Properties.
Formula
C18H20N2O6
Formula mass
360.37
Melting point, °C
155 - 158
Boiling point, °C
489
Vapor pressure, mmHg
1E-9 (25 C)
Solubility in water
Insoluble
pKa/pKb
9.97 (pKa)
Heat of vaporization
75.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Compatible chemical-resistant gloves. Chemical safety goggles.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides.

Fire.
Flash Point,°C
250
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
2
 

Health.
Exposure effects
Harmful by inhalation, in contact with skin and if swallowed.
   Ingestion
Harmful if swallowed.
   Inhalation
Harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. Harmful if absorbed through skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.