Nitrogen mustard n-oxide hydrochloride
- 2-Chloro-n-(2-chloroethyl)-n-methylethanamine-n-oxide hydrochloride
- 2,2'-Dichloro-n-methyldiethylamine n-oxide hydrochloride
- Mechlorethamine oxide hydrochloride
- Methylbis(beta-dhloroethyl)amine n-oxide hydrochloride
- n-Methylbis(beta-chloroethyl)amine n-oxide hydrochloride
- n-Methylbis(2-chloroethyl)amine n-oxide hydrochloride
Prisms from acetone. Odorless.
Antineoplastic agent (non-usa use).
Registry Numbers and Inventories.
Tumorigen; Drug; Mutagen
Japan ENCS (MITI)
Melting point, °C
109 - 110
Solubility in water
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
With therapeutic use - 1. Anorexia, weakness, drowsiness, headache, and coma may occur during therapy. Considered teratogenic in animals and humans. <br>There have been at least two deformed children out of seven reported cases of women receiving mechlorethamine during pregnancy.
Irritation/vesication has been described.
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.