Nitrogen mustard n-oxide hydrochloride

  • 2-Chloro-n-(2-chloroethyl)-n-methylethanamine-n-oxide hydrochloride
  • 2,2'-Dichloro-n-methyldiethylamine n-oxide hydrochloride
  • Mechlorethamine oxide hydrochloride
  • Methylbis(beta-dhloroethyl)amine n-oxide hydrochloride
  • n-Methylbis(beta-chloroethyl)amine n-oxide hydrochloride
  • n-Methylbis(2-chloroethyl)amine n-oxide hydrochloride
Formula
C5H12Cl3NO
Structure
Description
Prisms from acetone. Odorless.
Uses
Antineoplastic agent (non-usa use).

Registry Numbers and Inventories.
CAS
302-70-5
RTECS
IA2275000
RTECS class
Tumorigen; Drug; Mutagen
Merck
12,5816
Beilstein/Gmelin
3912946
Beilstein Reference
4-04-00-00446
Japan ENCS (MITI)
Listed

Properties.
Formula
C5H11Cl2NO*ClH
Formula mass
208.51
Melting point, °C
109 - 110
Solubility in water
soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2B, CP65
Exposure effects
With therapeutic use - 1. Anorexia, weakness, drowsiness, headache, and coma may occur during therapy. Considered teratogenic in animals and humans. <br>There have been at least two deformed children out of seven reported cases of women receiving mechlorethamine during pregnancy.
   Skin
Irritation/vesication has been described.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.