Nitrosoethylmethylamine

  • Ethylmethylnitrosamine
  • Methylethylnitrosamine
  • N,N-Methylethylnitrosamine
  • Methylethylnitrosoamine
  • n-Methyl-n-nitrosoethanamine
Formula
C3H8N2O
Structure
Description
Yellow liquid.
Uses
Research chemical.

Registry Numbers and Inventories.
CAS
10595-95-6
RTECS
KR9200000
RTECS class
Tumorigen; Mutagen
Beilstein/Gmelin
1742021
Beilstein Reference
4-04-00-03386

Properties.
Formula
C3H8N2O
Formula mass
88.10
Boiling point, °C
163
Density
0.9448 g/cm3 (18 C)
Solubility in water
soluble
Partition coefficient, pKow
0.04

Hazards and Protection.
Storage
Storage should be close to laboratory where material is to be used, so that only small amounts need to be carried. Carcinogens should be kept in only one section of storage area, explosion-proof refrigerator or freezer as required. The area should be appropriately labeled. An inventory should be kept showing the quantity of carcinogen and date it was acquired. Facilities for dispensing should be contiguous to storage area.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Wear appropriate clothing to prevent any reasonable probability of skin contact. Wear eye protection to prevent any possibility of eye contact.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Stable at room temperature for more than 14 days in neutral or alkaline aqueous solution in dark slightly less stable in acidic solution; light sensitive, especially to UV light.
Incompatibilities
Strong oxidizing agents.

Fire.
Flash Point,°C
80
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Carcinogin
I-2B, CP65
Exposure effects
Seizures, cerebral edema, headache, and malaise have been reported. Fetal death, fetotoxicity, and other teratogenic effects were observed in rat and mouse studies. Pre- and post-implantation mortality and abortion were observed in rats. Abnormal changes in sperm morphology were detected in mice.
   Ingestion
Vomiting, gastrointestinal hemorrhage, and peritonitis have occurred.
   Inhalation
Pulmonary edema, congestion, and hemorrhagic areas have been reported.

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
   Skin
Remove contaminated clothing and jewelry. Wash the skin, including hair and nails, vigorously; do repeated soap washings. Discard contaminated clothing.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.