Nivalenol

  • 12,13-Epoxy-3a,4b,7a,15-tetrahydroxytrichothec-9-en-8-one
  • Trichothec-9-en-8-one, 12,13-epoxy-3,4,7,15-tetrahydroxy-, (3a,4b,7a)-
Formula
C15H20O7
Structure
Description
Crystals from methanol.
Uses
Implicated as a chemical warfare agent in southeast asia with t-2-toxin.

Registry Numbers and Inventories.
CAS
23282-20-4
RTECS
YD0165000
RTECS class
Tumorigen; Mutagen; Natural Product; Primary Irritant
Merck
12,6757
Beilstein/Gmelin
3625724

Properties.
Formula
C15H20O7
Formula mass
312.32
Melting point, °C
222
Decomposition point, °C
222-223
Solubility in water
Slightly soluble
pKa/pKb
11.79 (pKa)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Headache and vertigo may be present.
   Ingestion
Anorexia, vomiting and diarrhea, which may be bloody, may occur.
   Inhalation
Shortness of breath may occur.
   Skin
Contact with skin and eyes can cause coagulation necrosis.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
   Eyes
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Transport.
20. Alcohols. Glycols