Nogalamycin

  • Antibiotic-NSC-70845
  • Antibiotic-205T3
  • Nogalomycin
  • NSC-70845
  • U-15167
  • 2,6-Epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, 11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-a-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R,3S,4R,5R,6R,11S,13S,14R)-
Formula
C39H49NO16
Description
Orange-red solid.
Uses
An aromatic polyketide antibiotic that inhibits DNA topoisomerase I but has no effect on topoisomerase II. Inhibits the DNA unwinding activity of human DNA helicase II.

Registry Numbers and Inventories.
CAS
1404-15-5
RTECS
RA4550000
Merck
12,6767

Properties.
Formula
C39H49NO16
Formula mass
787.82
Melting point, °C
195 - 196 (decomposition)
Density
1.49 g/cm3 (20 C)
Solubility in water
Insoluble
pKa/pKb
6.21 (pKa)
Partition coefficient, pKow
5.80

Hazards and Protection.
Storage
Refrigerate (+4C). Protect from light. This product is stable for 2 years as supplied.

Fire.

Health.
Exposure effects

First aid
 

Transport.