Nonactin

  • Ammonium ionophore
  • 4,13,22,31,37,38,39,40-Octaoxapentacyclo(32.2.1.1(sup 7,10).1(sup 16,19).1(sup 25,28)) tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R-(1R*,2R*,5R*,7R*, 10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*))
Formula
C40H64O12
Structure
Description
Faintly yellow powder
Uses
Nonactin has an  inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.

Registry Numbers and Inventories.
CAS
6833-84-7
EC (EINECS/ELINCS)
229-911-3
22 24/25
RTECS
RH1685000
RTECS class
Drug; Natural Product
Merck
12,6770
Beilstein/Gmelin
76434
Beilstein Reference
5-19-12-00751

Properties.
Formula
C40H64O12
Formula mass
736.94
Melting point, °C
148 - 149
Boiling point, °C
891
Vapor pressure, mmHg
2E-32 (25 C)
Density
1.13 g/cm3
Solubility in water
Insoluble
Heat of vaporization
129.5 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Protective gloves. Chemical safety goggles.
Respirators
Wear dust mask.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide.

Fire.
Flash Point,°C
353
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Avoid contact and inhalation.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.