- Ammonium ionophore
- 4,13,22,31,37,38,39,40-Octaoxapentacyclo(188.8.131.52(sup 7,10).1(sup 16,19).1(sup 25,28)) tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R-(1R*,2R*,5R*,7R*, 10S*,11S*,14S*,16S*,19R*,20R*,23R*,25R*,28S*,29S*,32S*,34S*))
Faintly yellow powder
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.
Registry Numbers and Inventories.
Drug; Natural Product
Melting point, °C
148 - 149
Boiling point, °C
Vapor pressure, mmHg
2E-32 (25 C)
Solubility in water
Heat of vaporization
Hazards and Protection.
Keep tightly closed. Store at 2-8 C
Protective gloves. Chemical safety goggles.
Wear dust mask.
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stable at normal temperatures and pressures.
Strong oxidizing agents.
Carbon monoxide, Carbon dioxide.
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Emits toxic fumes under fire conditions.
Avoid contact and inhalation.
May be harmful if swallowed.
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
May cause skin irritation. May be harmful if absorbed through the skin.
May cause eye irritation.
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
In case of contact, immediately wash skin with soap and copious amounts of water.
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.