Norfloxacin

  • AM-715
  • Baccidal
  • 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid
  • MK-366
Formula
C16H18FN3O3
Structure
Uses
Antibiotic. Inhibits the activity of a bacterial enzyme (gyrase) that is necessary for proper DNA formation and replication.

Registry Numbers and Inventories.
CAS
70458-96-7
EC (EINECS/ELINCS)
274-614-4
22 24/25
RTECS
VB2005000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,6793
Beilstein/Gmelin
567897
Beilstein Reference
5-23-03-00135
Canada DSL/NDSL
DSL
Korea ECL
Listed

Properties.
Formula
C16H18FN3O3
Formula mass
319.34
Melting point, °C
227 - 228
Boiling point, °C
556
Vapor pressure, mmHg
3E-13 (25 C)
Solubility in water
Soluble
pKa/pKb
2.75 (pKa)
Heat of vaporization
88.1 kJ/mol

Hazards and Protection.
Storage
Keep tightly closed. Store at 2-8 C
Protection
Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust.
Respirators
Wear dust mask.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen fluoride.

Fire.
Flash Point,°C
290
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Avoid contact and inhalation.
   Ingestion
May be harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation. May be harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
   Skin
In case of contact, immediately wash skin with soap and copious amounts of water.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.