Nortriptyline

  • Allegron
  • Ateben
  • Avantyl
  • Demethylamitryptylene
  • 5-[3-(Methylamino)propylidene]dibenzo[a,e]cyclohepta[1,5]diene
  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-
Formula
C19H21N
Structure
Uses
Medication.

Registry Numbers and Inventories.
CAS
72-69-5
EC (EINECS/ELINCS)
200-788-8
RTECS
HO9800000
RTECS class
Drug; Human Data
Merck
12,6812
Beilstein/Gmelin
2216786
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C19H21N
Formula mass
263.38
Solubility in water
Insoluble
pKa/pKb
3.92 (pKb)

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
Sensitive to light.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Respiratory depression may occur rapidly after overdose. Both elevated body temperature and reduced body temperature have been reported. Abnormally low blood pressure occurs with severe overdose. Rapid heart rate is a common anticholinergic effect. CNS depression, lethargy, disorientation, and ataxia are common.
   Ingestion
Bowel ischemia, pseudo-obstruction and esophageal spasm have been associated with overdose. Decreased GI motility and delayed gastric emptying are common anticholinergic effects. Pancreatitis is a rare effect of overdose.
   Inhalation
Respiratory depression is common with significant overdoses and may develop rapidly. Atelectasis, aspiration pneumonitis, pneumonia and ARDS may develop in patients with severe overdose.
   Eyes
Mydriasis, blurred vision and dry mouth are common anticholinergic effects. Nystagmus may occur.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.