n-Amyl methyl ketone

  • Methyl amyl ketone
  • Heptan-2-one
  • 2-Heptanone
Formula
CH3(CH2)4COCH3
Structure
Description
Water-white liquid with a penetrating fruity odor.
Uses
Industrial solvent, solvent for synthetic resin finishes, fragrance ingredient in creams, lotions, perfumes, soaps & detergents, flavor ingredient in foods, inert reaction medium.

Registry Numbers and Inventories.
CAS
110-43-0
EC (EINECS/ELINCS)
203-767-1
EC Index Number
606-024-00-3
EC Class
Flammable; Harmful
R 10 20/22
RTECS
MJ5075000
RTECS class
Primary Irritant
UN (DOT)
1110
Merck
13,4683
Beilstein/Gmelin
1699063
Beilstein Reference
4-01-00-03318
Swiss Giftliste 1
G-2267
Canada DSL/NDSL
DSL
US TSCA
Listed
Austrailia AICS
Listed
New Zealand
Listed
Japan ENCS (MITI)
Listed
Korea ECL
Listed

Properties.
Formula
C7H14O
Formula mass
114.19
Melting point, °C
-35
Boiling point, °C
150
Vapor pressure, mmHg
3
Vapor density (air=1)
3.9
Saturation Concentration
2,100 ppm at 25 C; 2,760 ppm at 25 C (calculated)
Evaporization number
17.4 (diethyl ether = 1)
Odor Threshold Odor threshold About 0.020 ppm
Critical temperature
338
Critical pressure
29.02
Density
0.8111 g/cm3
Solubility in water
0.43 g/100 mL.
Viscosity
0.77 cp (25 C)
Surface tension
26.17 g/s2
Refractive index
1.40935 (15 C)
Partition coefficient, pKow
1.98
Heat of fusion
19.7 kJ/mol
Heat of vaporization
46.10 kJ/mol

Hazards and Protection.
Storage
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
B3 D2B
Handling
Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Disposal code
1
Stability
Stable under normal temperatures and pressures.
Incompatibilities
Strong oxidizing agents, strong acids, bases.
Decomposition
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Fire.
Flash Point,°C
49
Autoignition, °C
532
Upper exp. limit, %
5.5
Lower exp. limit, %
1
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Use agent most appropriate to extinguish fire. Do NOT use straight streams of water.
Fire potential
Moderate when exposed to heat or flame
Hazards
Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.
Combustion products
Irritating vapors and toxic gases, such as carbon dioxide and carbon monoxide, may be formed when involved in fire.
Health
1
 
Flammability
2
 
 
Reactivity
0
 

Health.
Exposure limit(s)
TLV: 50 ppm; 233 mg/m3 (ACGIH 1995-1996). OSHA PEL: TWA 100 ppm (465 mg/m3) NIOSH REL: TWA 100 ppm (465 mg/m3) NIOSH IDLH: 800 ppm
Poison_Class
4
Exposure effects
Limited studies have generally documented little or no effect of ketones on reproduction in experimental animals. Human data is lacking. 2,5-Hexanedione has an effect on spermatogenesis in male experimental animals.
   Ingestion
Ingestion of large amounts may cause gastrointestinal irritation.
   Inhalation
May cause respiratory tract irritation. Vapors may cause dizziness or suffocation.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Transport.
UN number
1110
Response guide
Hazard class
3
Packing Group
III
 
USCG CHRIS Code
MAK
 
HS Code
2914 19 90
 
Std. Transport #
4912032
 
IMO Chemical Code
18
IMO Pollution Category
D