Ochratoxin A

  • Phenylalanine-ochratoxin A
  • Phe-OTA
  • L-Phenylalanine, N-[[(3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-
Formula
C20H18ClNO6
Structure
Description
White crystalline powder.
Uses
Research chemical.

Registry Numbers and Inventories.
CAS
303-47-9
EC (EINECS/ELINCS)
206-143-7
RTECS
AY4375000
RTECS class
Tumorigen; Mutagen; Reproductive Effector; Natural Product
UN (DOT)
3172
Beilstein/Gmelin
1301486
Beilstein Reference
5-18-09-00056

Properties.
Formula
C20H18ClNO6
Formula mass
403.84
Melting point, °C
169
Density
1.366 g/cm3
Solubility in water
Insoluble
pKa/pKb
3.46 (pKa)
Partition coefficient, pKow
4.74

Hazards and Protection.
Storage
Store in a tightly closed container. Store in a dry area. Refrigerator (approx 4 C).
Handling
Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Protection
Eyes: Wear chemical goggles and face shield. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
Unstable to light and air; fading and degradation upon brief exposure to light, esp @ high humidity ethanol solution are stable for more than yr if kept in dark and cold fairly stable in cereal products up to 35% survives autoclaving for up to 3 hr.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, oxides of nitrogen, carbon dioxide.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Fire potential
This material is probably combustible.
Hazards
When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.
Combustion products
Fire may produce irritating, corrosive and/or toxic gases.

Health.
Carcinogin
I-2B, N-2, CP65
Exposure effects
May cause kidney injury. May cause cancer according to animal studies.
   Ingestion
May be fatal if swallowed. May cause irritation of the digestive tract.
   Inhalation
May be fatal if inhaled.
   Skin
May be fatal if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If victim is conscious and alert, give 2-4 cupfuls of milk or water. SPEED IS ESSENTIAL. A DOCTOR MUST BE NOTIFIED AT ONCE.
   Inhalation
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
   Skin
Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number
3172
Response guide
Hazard class
6.1
Packing Group
II