Okadaic acid

  • 1,7-Dioxaspiro[5.5]undecane, acanthifolicin deriv.
  • Acanthifolicin, 9,10-deepithio-9,10-didehydro-
  • Spiro[furan-2(3H),2'(3'H)-pyrano[3,2-b]pyran], acanthifolicin deriv.
  • NSC 677083
Formula
C44H68O13
Structure
Description
odorless clear to white solid
Uses
Biochemical tool as tumor promoter and probe of cellular regulation.

Registry Numbers and Inventories.
CAS
78111-17-8
RTECS
AA8227800
RTECS class
Tumorigen; Mutagen; Natural Product
Merck
12,6958
Beilstein/Gmelin
4640246
New Zealand
Listed

Properties.
Formula
C44H68O13
Formula mass
805.02
Melting point, °C
171 - 175
Vapor pressure, mmHg
4E-40 (25 C)
Solubility in water
Insoluble
pKa/pKb
3.87 (pKa)
Partition coefficient, pKow
3.91

Hazards and Protection.
Storage
Store in a tightly closed container. Deep freeze (below -20 C).
Handling
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Protection
Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks
Vacuum or sweep up material and place into a suitable disposal container.
Stability
No data.
Incompatibilities
Strong oxidizing agents.
Decomposition
Hydrogen chloride, carbon monoxide, carbon dioxide, phosgene gas.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Health.
Exposure effects
   Ingestion
Harmful if swallowed. The toxicological properties of this substance have not been fully investigated.
   Inhalation
Harmful if inhaled. The toxicological properties of this substance have not been fully investigated.
   Skin
Harmful if absorbed through the skin.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
Get medical aid. Wash mouth out with water.
   Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
   Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.