Omeprazole

  • Gastrozole
  • Prilosec
  • lcometion
  • Roweprazol
  • Sanamidol
  • 1H-Benzimidazole, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-
Formula
C17H19N3O3S
Structure
Description
Crystals from acetonitrile.
Uses
Medication.

Registry Numbers and Inventories.
CAS
73590-58-6
RTECS
DD9087000
RTECS class
Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,6977
Beilstein/Gmelin
3628192
New Zealand
Listed

Properties.
Formula
C17H19N3O3S
Formula mass
345.42
Melting point, °C
144 - 146
Density
1.329 g/cm3
Solubility in water
Slightly soluble
pKa/pKb
4.92 (pKb)
Partition coefficient, pKow
2.38

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
confusion, somnolence, headache, dizziness and blurred vision have been reported with therapeutic use and may follow overdoses of omeprazole. No embryonic, teratogenic, or fetotoxic effects have been seen in animals tested. <br>Omeprazole has been shown to cross the placenta in animals and humans.
   Skin
Lichen spinulosis and exfoliative dermatitis have been associated with omeprazole therapy.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.