- O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorothioate
- O,O-Dimethyl S-methylcarbamoylmethyl phosphorothioate
- O,O-Dimethyl phosphorothioate S ester with 2-mercapto-N-methylacetamide
Colorless liquid. Mercaptan-like odor.
Registry Numbers and Inventories.
EC Index Number
Toxic; Harmful; Dangerous for the Environment
Agricultural Chemical and Pesticide; Mutagen
Swiss Giftliste 1
Melting point, °C
Boiling point, °C
150 - 152 (0.1 torr)
1.3943 g/cm3 (20 C)
Solubility in water
1.4987 (20 C)
Partition coefficient, pKow
-0.74 at 20 C
Hazards and Protection.
Rooms used for storage only should be soundly constructed and fitted with secure locks. Floors should be kept clear and pesticides clearly identified if repacking is carried out in storage rooms, adequate light should be available; floors should be impervious and sound. Pesticides pesticides containers must be provided with labels indicating the degree of toxicity of the product they contain. The labels must not only give a short description of how to use the prepn, but also state basic precautions to be taken when applying it. Organophosphorus pesticides pesticides of any degree of toxicity should be transported in containers which are clearly labelled, leak-proof, and not easily damaged. They should never be transported or stored beside, or above any type of food, and all spillages should be immediately reported.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Workers handling and applying organophosphate pesticides must be given personal protective equipment comprising overalls made of a tight fabric or polyvinyl chloride, gloves, and rubber boots. The eyes should be protected by goggles.
Respiratory protection (supplied-air respirator with full facepiece or self-contained breathing apparatus) should be available where these compounds are manufactured or used and should be worn in case of emergency and overexposure.<BR>Must wear a respirator with an activated-carbon gas filter cartridge affording protection for a determined number of working hours.
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS.
Hydrolyzed in alkaline media; relatively slowly hydrolyzed in acidic media.
Incompatible with alkaline materials.
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use alcohol foam, carbon dioxide or dry chemical.
Combustible material: may burn but does not ignite readily.
Containers may explode when heated.
Fire may produce irritating, corrosive and/or toxic gases.
Reduced body temperature or elevated body temperature may occur. Low heart rate and abnormally low blood pressure may develop after moderate to severe poisoning. Rapid heart rate, elevated blood pressure, and changes in respiratory rate may also occur. Early giddiness, anxiety headache, and restlessness followed by ataxia, drowsiness, and confusion are common with moderate to severe exposures. Sporadic reports of human birth defects related to organophosphates have not been fully verified.
Nausea, vomiting, abdominal cramps, and diarrhea are common muscarinic effects. Both painless and frank clinical pancreatitis have been reported.
Increased bronchial secretions, bronchospasm and dyspnea occur in moderate to severe exposures. Respiratory failure and non-cardiogenic pulmonary edema may occur with severe poisonings. Acute respiratory insufficiency is the main cause of death in acute poisonings. The hydrocarbon vehicle may cause chemical pneumonitis.
Profuse sweating is common. Pallor may be noted. Dermal sensitization has been reported.
Constriction of the pupil, tearing, and blurred vision are common. Prolonged dialation of the pupils may occur. Salivation commonly occurs.
Seek medical assistance.
Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with beta2 agonist and corticosteroid aerosols.
Systemic effects can occur from dermal exposure to organophosphates. Remove contaminated clothing, wash skin, hair and nails vigorously with repeated soap washings. Leather absorbs pesticides; all contaminated leather should be discarded. Rescue personnel and bystanders should avoid direct contact with contaminated skin, clothing, or other objects. Treatment should include recommendations listed in the oral exposure section when appropriate.
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Patients symptomatic following exposure should be observed in a controlled setting until all signs and symptoms have fully resolved. Treatment should include recommendations listed in the oral exposure section when appropriate.
I; II; III