- Gratus strophanthin
Odorless, white crystals or crystalline powder as an octahydrate. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
Registry Numbers and Inventories.
EC Index Number
Toxic; Danger of cumulative effects
Drug; Mutagen; Natural Product
Melting point, °C
Solubility in water
slightly soluble@ 20 C
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
(Non-Specific -- Medcines, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. If water pollution occurs, notify appropriate authorities. Shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move container from spill area. Large spills: dike far ahead of spill for later disposal.
Stable in air, but is affected by light ouabain octahydrate.
(Non-Specific -- Medicine, n.o.s.) Cool containers that are exposed to flames with water from the side until well after fire is out. For massive fires use unmanned hose holder or monitor nozzles; if this is impossible, withdraw and let fire burn. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.(Non-Specific -- Medicine, n.o.s.) For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam.
When heated to decomposition, it emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (ouabain octahydrate)
Drowsiness, lethargy, and headache may be noted. Cardiac glycosides can cross the placenta and enter the breast milk, but have not been associated with congenital malformations in humans.
Nausea and vomiting may be noted.
It is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.
USCG CHRIS Code