Ouabain

  • Acocantherin
  • Astrobain
  • 3-((6-Deoxy-alpha-L-Mannopyranosyl)oxy)-1,5,11-alpha,14,19-Pentahydroxycard-20(22)-Enolide
  • Gratus strophanthin
  • Gratibain
Formula
C29H44O12
Structure
Description
Odorless, white crystals or crystalline powder as an octahydrate. Also recommended in treatment of atrial or nodal paroxysmal tachycardia and atrial flutter.
Uses
Medication.

Registry Numbers and Inventories.
CAS
630-60-4
EC (EINECS/ELINCS)
211-139-3
EC Index Number
614-025-00-5
EC Class
Toxic; Danger of cumulative effects
RTECS
RN3675000
RTECS class
Drug; Mutagen; Natural Product
Merck
12,7031
Beilstein/Gmelin
101712
Beilstein Reference
5-18-05-00625
Canada DSL/NDSL
NDSL
US TSCA
Listed

Properties.
Formula
C29H44O12
Formula mass
584.66
Melting point, °C
241
Solubility in water
slightly soluble@ 20 C

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
(Non-Specific -- Medcines, n.o.s.) Keep unnecessary people away; isolate hazard area and deny entry. Stay upwind; keep out of low areas. If water pollution occurs, notify appropriate authorities. Shut off ignition sources; no flares, smoking or flames in hazard area. Keep combustibles (wood, paper, oil, etc.) away from spilled material. Do not touch spilled material. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move container from spill area. Large spills: dike far ahead of spill for later disposal.
Stability
Stable in air, but is affected by light ouabain octahydrate.

Fire.
Fire fighting
(Non-Specific -- Medicine, n.o.s.) Cool containers that are exposed to flames with water from the side until well after fire is out. For massive fires use unmanned hose holder or monitor nozzles; if this is impossible, withdraw and let fire burn. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.(Non-Specific -- Medicine, n.o.s.) For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam.
Hazards
When heated to decomposition, it emits acrid smoke and fumes. Hydrolysis yields one mole ouabagenin and one mole rhamnose. Stable in air, but affected by light (ouabain octahydrate)

Health.
Exposure effects
Drowsiness, lethargy, and headache may be noted. Cardiac glycosides can cross the placenta and enter the breast milk, but have not been associated with congenital malformations in humans.
   Ingestion
Nausea and vomiting may be noted.
   Inhalation
It is classified as extremely toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for 70 kg (150-lb.) person. Exposure may result in respiratory and cardiac failure, and/or hyperalkemia. Patients with frequent premature ventricular heart beats or who have received any preparation of digitalis during preceding three weeks are prone to toxicity.
   Skin
See inhalation.
   Eyes
See inhalation

First aid
 
   Ingestion
The possible benefit of early removal of some ingested material by cautious gastric lavage must be weighed against potential complications of bleeding or perforation. Activated charcoal activated charcoal binds most toxic agents and can decrease their systemic absorption if administered soon after ingestion. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.
USCG CHRIS Code
OAB