Oxatomide

  • 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-2-benzimidazolinone
  • 1-(3-(4-(Diphenylmethyl)-1-piperazinyl)propyl)-1,3-dihydro-2H-benzimidazol-2-one
  • KW-4354
  • Oxatimide
  • Oxatomida
Formula
C27H30N4O
Structure
Description
White powder.
Uses
A histamine H1-receptor antagonist. May be useful in managing asthma

Registry Numbers and Inventories.
CAS
60607-34-3
EC (EINECS/ELINCS)
262-320-9
RTECS
DE2276000
RTECS class
Drug; Reproductive Effector
Merck
12,7058
Beilstein/Gmelin
4724760
Beilstein Reference
6-24
Austrailia AICS
Listed

Properties.
Formula
C27H30N4O
Formula mass
426.56
Melting point, °C
153 - 155
Solubility in water
Insoluble
pKa/pKb
6.87 (pKb)

Hazards and Protection.
Storage
Keep tightly closed.
Protection
Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.
Respirators
Government approved respirator.
Small spills/leaks
Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability
Stable at normal temperatures and pressures.
Incompatibilities
Oxidizing agents, Strong acids.
Decomposition
Carbon monoxide, Carbon dioxide, Nitrogen oxides.

Fire.
Fire fighting
Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Hazards
Emits toxic fumes under fire conditions.
Health
1
 
Flammability
0
 
 
Reactivity
0
 

Health.
Exposure effects
Harmful. Harmful if swallowed.
   Ingestion
Harmful if swallowed.
   Inhalation
May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
   Skin
May cause skin irritation.
   Eyes
May cause eye irritation.

First aid
 
   Ingestion
If swallowed, wash out mouth with water provided person is conscious. Call a physician.
   Inhalation
If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
   Skin
In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
   Eyes
In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Transport.