Odorless creamy-white to pale-yellow powder or white crystalline solid. Bitter taste.
Registry Numbers and Inventories.
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Japan ENCS (MITI)
Melting point, °C
196 - 198
Boiling point, °C
Vapor pressure, mmHg
4E-11 (25 C)
Solubility in water
Partition coefficient, pKow
Heat of fusion
Heat of vaporization
Hazards and Protection.
Store below 40C (104F), preferably between 15 and 30C (59 and 86F), in a well-closed container.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stable in light stable as solid or in neutral solution but hydrolyzed by acids.
Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
This material is probably combustible.
Reduced body temperature, respiratory depression, abnormally low blood pressure and low heart rate have been reported in overdose. ataxia, lethargy, sleepiness and slurred speech are common. Coma has been reported. Benzodiazepines may induce or worsen dyskinesia. Patients may be agitated (paradoxical effect) or disorientated, and may experience memory loss, confusion, and difficulty concentrating. Benzodiazepines are excreted in breast milk and may produce effects in the nursing infant. <br>Administration of benzodiazepines prior to delivery may produce signs of poisoning in the neonate. A condition called floppy infant syndrome, characterized by hypotonia that may last several days, may may occur following maternal diazepam use.
Nausea and vomiting have been reported.
Symptoms of exposure to this compound include sedation, nausea, drowsiness, ataxia and coma (from large doses). Other symptoms include vomiting, lethargy, hyporeflexia, muscular weakness, dysarthria, nystagmus, hypotension, respiratory failure and death from respiratory or cardiac arrest. Exposure can cause syncope, liver damage, bone marrow damage and sensitivity reactions.
Bullae have been reported.
For pure benzodiazepine ingestions, effects should be minimal, but may include prolonged dialation of the pupils, nystagmus, and divergence paralysis. Constriction of the pupil is also observed.
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.