White to yellowish white, crystalline powder. Odorless.
Registry Numbers and Inventories.
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Japan ENCS (MITI)
Melting point, °C
124 - 130
Solubility in water
Hazards and Protection.
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Strong oxidizing agents.
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Vital sign changes in severe overdose may include elevated blood pressure or abnormally low blood pressure, rapid heart rate or low heart rate, apnea, and elevated body temperature or reduced body temperature. ataxia, lethargy, stupor, vertigo, seizures, agitation, coma, and hallucinations, and paresthesias may occur with severe overdose. CNS depression was less frequent with dipyrone than with aminopyrine and propyphenzone overdose.
Toxic gastroenteritis, with nausea, vomiting, and epigastric pain, is common, reported in 45% of dipyrone cases. Gastric ulceration may occur.
Dyspnea and ARDS have been reported with severe overdose. Sudden apnea has been reported with aminopyrine overdose. Patients with aspirin-induced asthma may develop bronchospasm after therapeutic use of pyrazoles.
Skin rash and excessive perspiration may occur following overdose.
Tinnitus and hearing loss may occur.
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.