Oxyphenbutazone

  • Artroflog
  • BM1
  • Butanora
  • Butapirone
  • Oxyphenylbutazone
  • 4-Butyl-1-(4-Hydroxyphenyl)-2-phenyl-3,5-Pyrazolidinedione
Formula
C19H20N2O3
Structure
Description
White to yellowish white, crystalline powder. Odorless.
Uses
Medication.

Registry Numbers and Inventories.
CAS
129-20-4
EC (EINECS/ELINCS)
204-936-2
RTECS
UQ8400000
RTECS class
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
Merck
12,7106
Beilstein/Gmelin
307474
Beilstein Reference
5-24-05-00404
Austrailia AICS
Listed
Japan ENCS (MITI)
Listed

Properties.
Formula
C19H20N2O3
Formula mass
324.38
Melting point, °C
124 - 130
Density
1.304 g/cm3
Solubility in water
Slightly soluble

Hazards and Protection.
Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
Small spills/leaks
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
Stability
No data.
Incompatibilities
Strong oxidizing agents.

Fire.
Fire fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Health.
Exposure effects
Vital sign changes in severe overdose may include elevated blood pressure or abnormally low blood pressure, rapid heart rate or low heart rate, apnea, and elevated body temperature or reduced body temperature. ataxia, lethargy, stupor, vertigo, seizures, agitation, coma, and hallucinations, and paresthesias may occur with severe overdose. CNS depression was less frequent with dipyrone than with aminopyrine and propyphenzone overdose.
   Ingestion
Toxic gastroenteritis, with nausea, vomiting, and epigastric pain, is common, reported in 45% of dipyrone cases. Gastric ulceration may occur.
   Inhalation
Dyspnea and ARDS have been reported with severe overdose. Sudden apnea has been reported with aminopyrine overdose. Patients with aspirin-induced asthma may develop bronchospasm after therapeutic use of pyrazoles.
   Skin
Skin rash and excessive perspiration may occur following overdose.
   Eyes
Tinnitus and hearing loss may occur.

First aid
 
   Ingestion
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
   Inhalation
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
   Skin
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
   Eyes
If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Transport.